Journal article
A novel treatment of global cerebral ischaemia with a glycine partial agonist
European journal of pharmacology, v 219(1)
1992
PMID: 1327834
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Chronic treatment of gerbils with 1-aminocyclopropanecarboxylic acid (a high affinity, partial agonist at strychnine-insensitive glycine receptors) resulted in a 3-fold increase in survival, a significant improvement in neurological status, and an extensive protection of vulnerable brain regions following severe forebrain ischaemia. A bolus of 1-aminocyclopropanecarboxylic acid 30 min prior to ischaemia did not further improve outcome compared to gebrils receiving their last injection 24 h to ischaemia. These findings are consistent with the hypothesis that chronic treatment with a glycine partial agonist desensitizes the N-methyl-D-aspartate receptor complex. Pharmacological intervention at the strychnine-insensitive glycine receptor may be an effective means of ameliorating the consequences of neuronal degeneration caused by excitotoxic phenomena.
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Details
- Title
- A novel treatment of global cerebral ischaemia with a glycine partial agonist
- Creators
- Dag K.J.E. Von Lubitz - Hahnemann University HospitalR.C.-S. Lin - Hahnemann University HospitalRobert J. McKenzie - Hahnemann University HospitalThomas M. Devlin - Hahnemann University HospitalR. Tyler McCabe - Laboratory of Neuroscience, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
- Publication Details
- European journal of pharmacology, v 219(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:A1992JJ61100023
- Scopus ID
- 2-s2.0-0026764263
- Other Identifier
- 991019184181304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy