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A paradigm for determination of direct drug-induced modulatory alterations in Purkinje cell activity during treadmill locomotion
Journal article   Peer reviewed

A paradigm for determination of direct drug-induced modulatory alterations in Purkinje cell activity during treadmill locomotion

Sheryl S. Smith, John K. Chapin and Susan S Smith
Journal of neuroscience methods, v 21(2), pp 335-344
1987
DOI: https://doi.org/10.1016/0165-0270(87)90127-0
PMID: 3682882
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Cerebellar Purkinje cell Evoked Evoked discharge Neuromodulation Sex steroid spontaneous ratio Treadmill locomotion
This paper describes a paradigm employing chronic single unit recording techniques and videotape analysis of treadmill locomotion in order to determine drug-induced modulation of sensorimotor neuronal activity. Animals implanted with a chronic headstage microdrive unit and an indwelling jugular cannula are trained to walk on a treadmill (10 s on, 10 s off). Characteristically, cerebellar Purkinje cells recorded 1–1.5 mm from midline, exhibit increased rates of discharge in phase with movement of specific limbs during a particular stage of the step-swing cycle, as assessed by video analysis of locomotor patterns. Drug-induced alterations in this movement-correlated discharge relative to changes in the spontaneous firing rate can then be determined to assess drug-induced neuromodulatory effects beyond general non-specific excitatory or inhibitory actions.

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7 citations in Web of Science
6 citations in Scopus

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Web of Science research areas
Biochemical Research Methods
Neurosciences
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