Journal article
A peptide-loaded dendritic cell based cytotoxic T-lymphocyte (CTL) vaccination strategy using peptides that span SIV Tat, Rev, and Env overlapping reading frames
Retrovirology, v 3(1), pp 1-1
06 Jan 2006
PMID: 16398928
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
CTL based vaccine strategies in the macaque model of AIDS have shown promise in slowing the progression to disease. However, rapid CTL escape viruses can emerge rendering such vaccination useless. We hypothesized that such escape is made more difficult if the immunizing CTL epitope falls within a region of the virus that has a high density of overlapping reading frames which encode several viral proteins. To test this hypothesis, we immunized macaques using a peptide-loaded dendritic cell approach employing epitopes in the second coding exon of SIV Tat which spans reading frames for both Env and Rev. We report here that autologous dendritic cells, loaded with SIV peptides from Tat, Rev, and Env, induced a distinct cellular immune response measurable
ex vivo
. However, conclusive
in vivo
control of a challenge inoculation of SIVmac239 was not observed suggesting that CTL epitopes within densely overlapping reading frames are also subject to escape mutations.
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Details
- Title
- A peptide-loaded dendritic cell based cytotoxic T-lymphocyte (CTL) vaccination strategy using peptides that span SIV Tat, Rev, and Env overlapping reading frames
- Creators
- Zachary Klase - Saint Michael's Medical CenterMichael J Donio - Saint Michael's Medical CenterAndrew Blauvelt - Oregon Health & Science UniversityPreston A Marx - Tulane UniversityKuan-Teh JeangStephen M Smith
- Publication Details
- Retrovirology, v 3(1), pp 1-1
- Publisher
- BioMed Central
- Number of pages
- 1
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000239282400001
- Scopus ID
- 2-s2.0-59149083219
- Other Identifier
- 991021902503204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Virology