Journal article
A polyclonal CD4+ and CD8+ lymphocytosis in a patient doubly infected with HTLV-1 and HIV-1: A clinical and molecular analysis
American journal of hematology, Vol.30(3), pp.128-139
01 Jan 1989
Abstract
HTLV-1 is associated with adult T-cell leukemia/lymphoma (ATL) characterized by monoclonal expansions of CD4+ T-lymphocytes. In this report, the authors describe a histologically benign, polyclonal HTLV-1 infection in a patient exhibiting both an absolute CD4+ and CD8+ lymphocytosis. Three T-cell lines containing integrated HTLV-1 proviral copies established from this patient were initially polyclonal, but with time all grew out the same two clones as determined by analysis of their T-cell antigen receptor beta chain gene rearrangements. The patient subsequently developed pulmonary and nasopharyngeal nodules containing HTLV-1 infected cells.
Metrics
1 Record Views
Details
- Title
- A polyclonal CD4+ and CD8+ lymphocytosis in a patient doubly infected with HTLV-1 and HIV-1: A clinical and molecular analysis
- Creators
- G EhrlichF R DaveyJ KirshnerJ SninskyS KwokD SlamonR KalishB Poiesz
- Publication Details
- American journal of hematology, Vol.30(3), pp.128-139
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Identifiers
- 991019196423004721