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Accepted (AM)Open Access (License Unspecified), Open
Journal article
A pooled analysis of cigarette smoking and risk of multiple myeloma from the international multiple myeloma consortium
Cancer epidemiology, biomarkers & prevention, v 24(3), pp 631-634
Mar 2015
PMID: 25538226
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Past investigations of cigarette smoking and multiple myeloma have been underpowered to detect moderate associations, particularly within subgroups. To clarify this association, we conducted a pooled analysis of nine case-control studies in the International Multiple Myeloma Consortium, with individual-level questionnaire data on cigarette smoking history and other covariates.
Using a pooled population of 2,670 cases and 11,913 controls, we computed odds ratios (OR) and 95% confidence intervals (CI) relating smoking to multiple myeloma risk using unconditional logistic regression adjusting for gender, age group, race, education, body mass index, alcohol consumption, and study center.
Neither ever smokers (OR, 0.95; 95% CI, 0.87-1.05), current smokers (OR, 0.82; 95% CI, 0.73-0.93), nor former smokers (OR, 1.03; 95% CI, 0.92-1.14) had increased risks of multiple myeloma compared with never smokers. Analyses of smoking frequency, pack-years, and duration did not reveal significant or consistent patterns, and there was no significant effect modification by subgroups.
Findings from this large pooled analysis do not support the hypothesis of cigarette smoking as a causal factor for multiple myeloma.
Cigarette smoking is one of the most important risk factors for cancer, but the association with multiple myeloma was inconclusive. This study had excellent power to detect modest associations, and had individual-level data to evaluate confounding and effect modification by potentially important factors that were not evaluated in previous studies. Our findings confirm that smoking is not a risk factor for multiple myeloma. Cancer Epidemiol Biomarkers Prev; 24(3); 631-4. ©2014 AACR.
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Details
- Title
- A pooled analysis of cigarette smoking and risk of multiple myeloma from the international multiple myeloma consortium
- Creators
- Gabriella Andreotti - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland.Brenda M Birmann - Brigham and Women's HospitalWendy Cozen - University of Southern CaliforniaAnneclaire J De Roos - Drexel UniversityBrian C H Chiu - University of ChicagoLaura Costas - University of BarcelonaSilvia de Sanjosé - University of BarcelonaKirsten Moysich - Roswell Park Cancer InstituteNicola J Camp - University of UtahJohn J Spinelli - University of British ColumbiaPunam Pahwa - University of SaskatchewanJames A Dosman - University of SaskatchewanJohn R McLaughlin - Lunenfeld-Tanenbaum Research InstitutePaolo Boffetta - Icahn School of Medicine at Mount SinaiAnthony Staines - Department of Public Health, Public Health University College, Dublin, Ireland.Dennis Weisenburger - City Of Hope National Medical CenterVéronique Benhaim-Luzon - International Agency For Research On CancerPaul Brennan - International Agency For Research On CancerAdele Seniori Costantini - Piedmont Reference Center for Epidemiology and Cancer PreventionLucia Miligi - Piedmont Reference Center for Epidemiology and Cancer PreventionMarcello Campagna - University of CagliariAlexandra Nieters - German Cancer Research CenterNikolaus Becker - German Cancer Research CenterMarc Maynadié - University of BurgundyLenka Foretová - Masaryk Memorial Cancer InstituteTongzhang Zheng - Yale UniversityGuido Tricot - University of IowaKevin Milliken - Fred Hutchinson Cancer Research CenterJoseph Krzystan - Information Management ServicesEmily Steplowski - Information Management ServicesDalsu Baris - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland.Mark P Purdue - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland.
- Publication Details
- Cancer epidemiology, biomarkers & prevention, v 24(3), pp 631-634
- Publisher
- American Association for Cancer Research (AACR)
- Grant note
- CA149445 / NCI NIH HHS R01 CA149445 / NCI NIH HHS P30 CA042014 / NCI NIH HHS N01CO12400 / NCI NIH HHS Z99 CA999999 / Intramural NIH HHS N01-CO-12400 / NCI NIH HHS R21 CA152336 / NCI NIH HHS P30 ES023515 / NIEHS NIH HHS HHSN261201000026C / NCI NIH HHS UL1 TR000430 / NCATS NIH HHS UL1 TR001067 / NCATS NIH HHS K07 CA115687 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000351953100021
- Scopus ID
- 2-s2.0-84927760381
- Other Identifier
- 991019168228804721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology
- Public, Environmental & Occupational Health