Journal article
A pre-vaccination immune metabolic interplay determines the protective antibody response to a dengue virus vaccine
Cell reports (Cambridge), v 43(7), 114370
23 Jul 2024
PMID: 38900640
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Protective immunity to dengue virus (DENV) requires antibody response to all four serotypes. Systems vaccinology identifies a multi-OMICs pre-vaccination signature and mechanisms predictive of broad antibody responses after immunization with a tetravalent live attenuated DENV vaccine candidate (Butantan-DV/ TV003). Anti-inflammatory pathways, including TGF-b signaling expressed by CD68low low monocytes, and the metabolites phosphatidylcholine (PC) and phosphatidylethanolamine (PE) positively correlate with broadly neutralizing antibody responses against DENV. In contrast, expression of pro-inflammatory pathways and cytokines (IFN and IL-1) in CD68hi hi monocytes and primary and secondary bile acids negatively correlates with broad DENV-specific antibody responses. Induction of TGF-b and IFNs is done respectively by PC/ PE and bile acids in CD68low low and CD68hi hi monocytes. The inhibition of viral sensing by PC/PE-induced TGF-b is confirmed in vitro. . Our studies show that the balance between metabolites and the pro- or anti-inflammatory state of innate immune cells drives broad and protective B cell response to a live attenuated dengue vaccine.
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Details
- Title
- A pre-vaccination immune metabolic interplay determines the protective antibody response to a dengue virus vaccine
- Creators
- Adam-Nicolas Pelletier - RPM Bioinfo Solut, St Therese, PQ, CanadaGabriela Pacheco Sanchez - Emory UniversityAbdullah Izmirly - King Abdulaziz UniversityMark Watson - CellCarta, Montreal, PQ, CanadaTiziana Di Pucchio - Emory UniversityKarina Inacio Carvalho - Hospital Israelita Albert EinsteinAbdelali Filali-Mouhim - Centre Hospitalier de l’Université de MontréalEustache Paramithiotis - CellCarta, Montreal, PQ, CanadaMaria do Carmo S. T. Timenetsky - Instituto Adolfo LutzAlexander Roberto Precioso - Instituto ButantanJorge Kalil - Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloMichael S. Diamond - Washington University in St. LouisElias K. Haddad - Drexel UniversityEsper G. Kallas - Instituto ButantanRafick Pierre Sekaly (Corresponding Author) - Emory University
- Publication Details
- Cell reports (Cambridge), v 43(7), 114370
- Publisher
- Elsevier
- Number of pages
- 23
- Grant note
- 5R01AI125202-03 / NIAID; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physician Assistant; Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:001292289100001
- Scopus ID
- 2-s2.0-85196203824
- Other Identifier
- 991022202121504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology