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A preliminary examination of brain morphometry in youth with Down syndrome with and without parent-reported sleep difficulties
Journal article   Open access   Peer reviewed

A preliminary examination of brain morphometry in youth with Down syndrome with and without parent-reported sleep difficulties

Nancy Raitano Lee, Megan Perez, Taralee Hamner, Elizabeth Adeyemi and Liv S. Clasen
Research in developmental disabilities, v 99, 103575
Apr 2020
DOI: https://doi.org/10.1016/j.ridd.2020.103575
PMID: 32106035
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483358View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Cerebral cortex Frontal lobe Magnetic resonance imaging Sleep apnea Trisomy 21
•Little is known about the brain in youth with Down syndrome and poor sleep (DS-S).•The current study examined brain morphometry in youth with DS-S.•The DS-S group had smaller total brain volume than youth with DS only.•Specific reductions were noted in several frontal, parietal, and temporal gyri.•More research is needed to further characterize the brain in youth with DS-S. Down syndrome is associated with poor sleep but little is known about its neural correlates. The current research compared brain morphometry in youth with Down syndrome with parent-reported sleep problems (DS-S) to peers with Down syndrome (DS) and typical development (TD) without parent-reported sleep problems matched on age (M = 15.15) and sex ratio (62 % female). Magnetic resonance imaging was completed on a 3 T scanner. Participants were stratified into groups based on parent-report: DS-S (n = 17), DS (n = 9), TD (n = 22). Brain morphometry, processed with the FreeSurfer Image Analysis Suite, was compared across groups. In addition, the co-occurrence of medical conditions in the DS groups was examined. Youth with DS-S had reduced total, frontal, parietal, and temporal brain volumes relative to DS and TD peers. They also had higher rates of congenital heart defects than the DS-only group; however, this comorbidity did not appear to account for morphometry differences. Parent-reported sleep problems in DS appear to relate to global and localized volume reductions. These preliminary results have implications for understanding the neural correlates of poor sleep in DS; they also highlight the importance of examining relations between sleep and other medical comorbidities.

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6 citations in Web of Science
6 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Education, Special
Rehabilitation
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