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Journal article
A pro longevity role for cellular senescence
GeroScience, v 42(3), pp 867-879
16 May 2019
PMID: 31098949
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cellular senescence is a fundamental process that may play positive or detrimental roles for the organism. It is involved in tissue development and in tumor prevention although during aging is becoming a detrimental process contributing to the decline of tissue functions. In previous investigations, we have uncovered a better capacity to detect DNA damage in cells from long-lived mammals. Here, we report that cultured cells derived from long-lived species have a higher propensity to undergo senescence when challenged with DNA damage than cells derived from short-lived species. Using a panel of cells derived from six mammals, which range in lifespan from 3-4 years up to 120 years, we examined cell cycle response, induction of apoptosis and of cellular senescence. All species exhibited a cell cycle arrest while induction of apoptosis was variable. However, a significant positive correlation was found between the relative percent of cells, within a population which entered senescence following damage, and the lifespan of the species. We suggest that cellular senescence may have a positive role during development allowing it to contribute to the evolution of longevity.
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Details
- Title
- A pro longevity role for cellular senescence
- Creators
- Amany Attaallah - Damanhour UniversityMonia Lenzi - University of BolognaSilvia Marchionni - University of BolognaGiacomo Bincoletto - University of BolognaVeronica Cocchi - University of BolognaEleonora Croco - University of BolognaPatrizia Hrelia - University of BolognaSilvana Hrelia - University of BolognaChristian Sell - Drexel UniversityAntonello Lorenzini - University of Bologna
- Publication Details
- GeroScience, v 42(3), pp 867-879
- Publisher
- Springer International Publishing
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000540149500005
- Scopus ID
- 2-s2.0-85072183328
- Other Identifier
- 991019168636104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Geriatrics & Gerontology