Journal article
A randomized trial of atropine regimens for treatment of moderate amblyopia in children
Ophthalmology (Rochester, Minn.), v 111(11), pp 2076-2085
01 Nov 2004
PMID: 15522375
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
OBJECTIVETo compare daily atropine to weekend atropine as prescribed treatments for moderate amblyopia in children younger than 7 years.DESIGNProspective, randomized multicenter clinical trial (30 sites).PARTICIPANTSOne hundred sixty-eight children younger than 7 years with amblyopia in the range of 20/40 to 20/80 associated with strabismus, anisometropia, or both.INTERVENTIONRandomization either to daily atropine or to weekend atropine for 4 months. Partial responders were continued on the randomized treatment until no further improvement was noted.MAIN OUTCOME MEASUREVisual acuity (VA) in the amblyopic eye after 4 months.RESULTSThe improvement in VA of the amblyopic eye from baseline to 4 months averaged 2.3 lines in each group. The VA of the amblyopic eye at study completion was either (1) at least 20/25 or (2) better than or equal to that of the sound eye in 39 children (47%) in the daily group and 45 children (53%) in the weekend group. The VA of the sound eye at the end of follow-up was reduced by 2 lines in one patient in each group. Stereoacuity outcomes were similar in the 2 groups.CONCLUSIONSWeekend atropine provides an improvement in VA of a magnitude similar to that of the improvement provided by daily atropine in treating moderate amblyopia in children 3 to 7 years old. This article contains additional online-only material available at http://www.ophsource.com/periodicals/ophtha.
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Details
- Title
- A randomized trial of atropine regimens for treatment of moderate amblyopia in children
- Creators
- Michael X Repka - Jaeb Center for Health ResearchSusan A CotterRoy W BeckRaymond T KrakerEileen E BirchDonald F EverettRichard W HertleJonathan M HolmesGraham E QuinnNicholas A SalaMitchell M ScheimanDavid R StagerDavid K WallaceThe Pediatric Eye Disease Investigator Group
- Publication Details
- Ophthalmology (Rochester, Minn.), v 111(11), pp 2076-2085
- Publisher
- Elsevier
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:000224771100016
- Scopus ID
- 2-s2.0-7444222244
- Other Identifier
- 991021900189704721
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- Web of Science research areas
- Ophthalmology