Journal article
A randomized trial of tirilazad mesylate in patients with acute stroke (RANTTAS)
Stroke (1970), v 27(9), pp 1453-1458
01 Sep 1996
PMID: 8784112
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background and Purpose
Tirilazad mesylate, a nonglucocorticoid 21-aminosteroid lipid peroxidation inhibitor, has shown promise as a neuroprotectant in experimental models of focal cerebral ischemia.
Methods
To test whether early treatment with tirilazad, 6 mg/kg per day for 3 days, would improve functional outcome after acute human stroke, 27 North American centers conducted a prospective, randomized, double-blinded, vehicle-controlled trial in patients with acute stroke treated within 6 hours of onset. The primary outcome measures were disability as measured by the Glasgow Outcome Scale and activities of daily living by the Barthel Index determined 3 months after stroke.
Results
From May 1993 through December 1994, 660 patients were randomized. The trial was prematurely terminated on the advice of an independent monitoring committee after review of outcome data at a preplanned interim analysis. In 556 fully eligible patients (276 tirilazad, 280 vehicle), the odds ratio of a favorable outcome in favor of tirilazad was 0.87 (95% confidence interval [CI], 0.60 to 1.25) for the Glasgow Outcome Scale and 0.87 (95% CI, 0.60 to 1.25) for the Barthel Index, after adjustment for imbalances between the groups in preexisting disability, prior stroke, and diabetes.
Conclusions
These observations suggest that tirilazad, 6 mg/kg per day for 3 days administered beginning at a median of 4.3 hours after stroke, does not improve overall functional outcome.
Metrics
Details
- Title
- A randomized trial of tirilazad mesylate in patients with acute stroke (RANTTAS)
- Creators
- P ScottW BarsanS FrederiksenS KronickB J ZinkR M DomeierJ C MitchinerF P JudgeR J LevyA AlexiouH ReinckeJ D SegallR SworJ GilroyM GoettingR JacksonD RichardsonJ CisekJ RandallS SchecterK WilkinsonB L WaltersR AdamsE CarlF NicholsD HessB BoopC EarleyD R SmithP KaplanC JohnsonC MorrowE FrohmanN PorterK FlaniganL MorgansternN HollandA SteinE AldrichG OylerE FaughtH LiuF ThomasD WenzelB M DajaniJ L PanR YapundichY FutatsugiS GeerlingsT MoskowitzA NicholasJ BrockingtonA CollinsJ M BaileyA TsengW J KoroshetzU CanA FelixM CudkowticzF BuonannoL SchwammM ElkindJ P KistlerS FinkelsteinJ ChaS MurphyH BlumenfeldM LopezBresnahanK GoslinS CramerN SuwanwelaD HomerJ CarpenterR WitykN MichelS GruffermanB LittH WeissA GuyotP PetersonL TvardekJ SchmidtA DeshpandeW FreijB GandhiF MinhasJ ShahC ZahkaA PennJ ShermanY L LiM G EllekerP StenersonH BrookeM AlJumahH AlAyafyR PokroyB HoppeR PascuzziM FarlowD RightmyerM BalesJ CaressC PettigrewC WaughA RockichR FallisA TikhtmanS StarkmanG SchubertB DobkinN MartinJ SaverS HansonA WeaverK PorthR MaganaJ DavenportF TaylorD FrekingD O HerosE SchnekM AlterR RibeiroM LloydS ScheinerA PuffS BoyleN GuptaK WhiteS CarneyM MoultonS LaCapraD HassardS RizwanA ShahA NewmarkA GuptaD ConeIqbal KhanB CohenR BopariJ OConnellA HussianK PatilJ ShojariR BellD GzechT MazerJ GrothusenP ReyesJ ArastuT StrassburgerC ThomasR WolfeJ FangM ScavinaW WolfeD ZeidwergJ ChavinO ShacharL SandlerD McGarrenD G JamiesonC GonnellaT M BosleyD A PollackJ C AndrefskyS HariharanA ChangM P LamonteJ ChampelloneH C HookerJ FellusVeronica Sosa - Pennsylvania HospitalS RaafM FriedmanG BurchD AtkinsC FoleyD BivinsW EliasD NolanM SiskJ WilsonA LloydG StephensR SurruscoC LothesW HumphriesS PastemakM DonatoE ManettaJ MitchellA BriggsM RorrerP OffermannW GroverB BoltonP LydenS LewisK RappM BrodyJ RothrockC JacksonP HuottC KushidaJ LissR ZweiferL CaylorD PhanZ MahdaviT TomH NoackG FordeD CameronB GriesdaleMakinC B BozekG SheppardS MasseyD ZontineN CroweK GustinP CaponeT E FeasbyC RobertsonM RorickM WinkelmanA LiskayJ SchmidleyM ColeM AlJaberiA AnagnosM AndersonC BamfordE FredericksonJ GordonS GrosserA KoriA KuntzM MuradW NasreddineA PetteeN RiachiH SchechtJ StahlJ SorianoJ SunshineJ SuarezJ VandersluisY AlLanhamA RamahiA ShuaibE KadribasicB StewartM BeaudryD BoivinG LyonsR L DougalJ P SimsarianM McGarveyD GrassL SigmundR KurtzkeL EberlyD LippsJ T FesenmeierK ViaterR AlonzoW CooperJ ScottP BustionJ PappasM FrazerE C HaleyW AlvesN F KassellK C JohnstonG FordN SolenskiD L ShreveS S WilkinsonS ClementsE CucciaL ElderM KellerR LackeyK MimmsP ProtzmanL SparrowA E LightfootB E BocchicchioP HalleyA PolinR PolinL J HwangM C WolfL L TruskowskiC GalbriethR JohnsonS JohnsonCharlene HillB WilsonA BartleyM RumfeltWingateM SmithT ChildressW J PowersM WalkerJ L FleissM FrankelR P SimonJ MarlerH P AdamsT G BrottS ChoiJ F KurtzkeJ C TOrnerG R PetersS EckertW J BryanM L BologaD LegaceK M Brennan
- Publication Details
- Stroke (1970), v 27(9), pp 1453-1458
- Publisher
- Amer Heart Assoc
- Number of pages
- 6
- Grant note
- R01-NS31554 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01NS031554 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Accelerated Career Entry Bachelor of Science in Nursing (BSN); College of Nursing and Health Professions
- Web of Science ID
- WOS:A1996VF03200001
- Scopus ID
- 2-s2.0-0043204506
- Other Identifier
- 991019174730804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Peripheral Vascular Disease