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Accepted (AM)Open Access (License Unspecified), Open
Journal article
A randomized trial to evaluate 2 hours of daily patching for strabismic and anisometropic amblyopia in children
Ophthalmology (Rochester, Minn.), v 113(6), pp 904-912
01 Jun 2006
PMID: 16751033
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: To compare 2 hours of daily patching (combined with 1 hour of concurrent near visual activities) with a control group of spectacle wear alone (if needed) for treatment of moderate to severe amblyopia in children 3 to 7 years old.
Design: Prospective randomized multicenter clinical trial (46 sites).
Participants: One hundred eighty children 3 to 7 years old with best-corrected amblyopic-eye visual acuity (VA) of 20/40 to 20/400 associated with strabismus, anisometropia, or both who had worn optimal refractive correction (if needed) for at least 16 weeks or for 2 consecutive visits without improvement.
Intervention: Randomization either to 2 hours of daily patching with 1 hour of near visual activities or to spectacles alone (if needed). Patients were continued on the randomized treatment (or no treatment) until no further improvement was noted.
Main Outcome Measure: Best-corrected VA in the amblyopic eye after 5 weeks.
Results: Improvement in VA of the amblyopic eye from baseline to 5 weeks averaged 1.1 lines in the patching group and 0.5 lines in the control group (P = 0.006), and improvement from baseline to best measured VA at any visit averaged 2.2 lines in the patching group and 1.3 lines in the control group (P < 0.001).
Conclusion: After a period of treatment with spectacles, 2 hours of daily patching combined with 1 hour of near visual activities modestly improves moderate to severe amblyopia in children 3 to 7 years old.
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Details
- Title
- A randomized trial to evaluate 2 hours of daily patching for strabismic and anisometropic amblyopia in children
- Creators
- David K. WallacePediatric Eye Dis Investigator GrpMitchell Scheiman - Pennsylvania College of Optometry (PCO)
- Publication Details
- Ophthalmology (Rochester, Minn.), v 113(6), pp 904-912
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- U54 EB015408 / NIBIB NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) EY11751; U10 EY011751; UG1 EY011751 / NEI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) U54EB015408 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) U10EY011751 / NATIONAL EYE INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:000238085900003
- Scopus ID
- 2-s2.0-33646904494
- Other Identifier
- 991021900188304721
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- Web of Science research areas
- Ophthalmology