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Journal article
A rare case of combined immunodeficiency with cytopenia whose symptoms were controlled by cyclosporine
OXFORD MEDICAL CASE REPORTS, v 2022(5), omac055
01 May 2022
PMID: 35619687
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Combined Immunodeficiency (CID) is a group of inborn error of Immunity (IEI) that may present with both infectious and non-infectious complications. Autoimmunity is an unusual presentation of CID and can be presented as cytopenia. The initial management of cytopenia is corticosteroids and IVIG. The role of other cytotoxic and immunosuppressive drugs in management of cytopenia is not fully understood. The objective of this clinical case report is to highlight the possibly beneficial role of cyclosporine in controlling cytopenia in CID patients. A 26-month-old child with generalized ecchymosis was referred to Mofid Children's Hospital in Tehran, Iran. Physical examination revealed no substantial findings other than ecchymosis, and complete blood count (CBC) revealed thrombocytopenia. Diagnosis of CID and cytopenia followed. The patient was treated by 5 times prednisolone and 4 times Rituximab. Finally, his ecchymosis was controlled by Cellcept, which was then tempered and substituted by cyclosporine.
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Details
- Title
- A rare case of combined immunodeficiency with cytopenia whose symptoms were controlled by cyclosporine
- Publication Details
- OXFORD MEDICAL CASE REPORTS, v 2022(5), omac055
- Publisher
- OXFORD UNIV PRESS; OXFORD
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000799445700002
- Scopus ID
- 2-s2.0-85133019695
- Other Identifier
- 991021861191404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology