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A rare case of cutaneous granular cell tumor with unusual Melan-A expression in a child
Journal article   Peer reviewed

A rare case of cutaneous granular cell tumor with unusual Melan-A expression in a child

Nina H. Cheng, David Smith, Carla Errickson and Shaymaa Ashi
Journal of cutaneous pathology, v 51(6), pp 434-438
01 Jun 2024
PMID: 38527927

Abstract

Life Sciences & Biomedicine Science & Technology Dermatology Pathology
Granular cell tumors (GCTs) are rare, indolent neoplasms classically characterized by eosinophilic granular cytoplasm, infiltrations of polygonal cells in the collagenous stroma, and pustulo-ovoid bodies of Milian. We describe a case of a 10-year-old female presenting with a GCT of the upper arm, remarkable for positive Melan-A expression without additional melanocytic features. The differentiation between granular cells versus melanocytic neoplasms carries significant implications for clinical management, and such diagnoses should be considered carefully in the setting of unusual immunophenotypes.

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Web of Science research areas
Dermatology
Pathology
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