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Journal article
A review of ferric citrate clinical studies, and the rationale and design of the Ferric Citrate and Chronic Kidney Disease in Children (FIT4KiD) trial
Pediatric nephrology (Berlin, West), Vol.37(11), pp.2547-2557
01 Nov 2022
PMCID: PMC9437144
PMID: 35237863
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Pediatric chronic kidney disease (CKD) is characterized by many co-morbidities, including impaired growth and development, CKD-mineral and bone disorder, anemia, dysregulated iron metabolism, and cardiovascular disease. In pediatric CKD cohorts, higher circulating concentrations of fibroblast growth factor 23 (FGF23) are associated with some of these adverse clinical outcomes, including CKD progression and left ventricular hypertrophy. It is hypothesized that lowering FGF23 levels will reduce the risk of these events and improve clinical outcomes. Reducing FGF23 levels in CKD may be accomplished by targeting two key stimuli of FGF23 production-dietary phosphate absorption and iron deficiency. Ferric citrate is approved for use as an enteral phosphate binder and iron replacement product in adults with CKD. Clinical trials in adult CKD cohorts have also demonstrated that ferric citrate decreases circulating FGF23 concentrations. This review outlines the possible deleterious effects of excess FGF23 in CKD, summarizes data from the adult CKD clinical trials of ferric citrate, and presents the Ferric Citrate and Chronic Kidney Disease in Children (FIT4KiD) study, a randomized, placebo-controlled trial to evaluate the effects of ferric citrate on FGF23 in pediatric patients with CKD stages 3-4 (ClinicalTrials.gov Identifier NCT04741646).
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Details
- Title
- A review of ferric citrate clinical studies, and the rationale and design of the Ferric Citrate and Chronic Kidney Disease in Children (FIT4KiD) trial
- Creators
- Mark R Hanudel - Mattel Children's HospitalMarciana L Laster - Mattel Children's HospitalAnthony A Portale - UCSF Benioff Children's HospitalAditi Dokras - The University of Texas Southwestern Medical CenterRaymond P Quigley - The University of Texas Southwestern Medical CenterGerman A Lozano Guzman - St. Christopher's Hospital for ChildrenJoshua J Zaritsky - St. Christopher's Hospital for ChildrenNicole A Hayde - Children's Hospital at MontefioreFrederick J Kaskel - Children's Hospital at MontefioreMark M Mitsnefes - Cincinnati Children's Hospital Medical CenterJorge A Ramirez - Arnold Palmer Hospital for ChildrenPeace D Imani - Texas Children's HospitalPoyyapakkam R Srivaths - Texas Children's HospitalAmy J Kogon - Children's Hospital of PhiladelphiaMichelle R Denburg - Children's Hospital of PhiladelphiaTom D Blydt-Hansen - British Columbia Children's HospitalLoretta Z Reyes - Children's Healthcare of AtlantaLarry A Greenbaum - Children's Healthcare of AtlantaDarcy K Weidemann - University of Missouri–Kansas CityBradley A Warady - University of Missouri–Kansas CityDavid A Elashoff - Department of Medicine/Biostatistics, Division of General Internal Medicine and Health Service Research, David Geffen School of Medicine at UCLA, Los Angeles, USASusan R Mendley - National Institute of Diabetes and Digestive and Kidney DiseasesTamara Isakova - Northwestern UniversityIsidro B Salusky - Mattel Children's Hospital
- Publication Details
- Pediatric nephrology (Berlin, West), Vol.37(11), pp.2547-2557
- Publisher
- Springer Nature
- Grant note
- K23 DK123378 / NIDDK NIH HHS U01 DK122013 / NIDDK NIH HHS UL1 TR002556 / NCATS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Identifiers
- 991021863012604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pediatrics
- Urology & Nephrology