Journal article
A role for the ETS domain transcription factor PEA3 in myogenic differentiation
Molecular and cellular biology, v 17(9), pp 5550-5558
Sep 1997
PMID: 9271430
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Activation of adult myoblasts called satellite cells during muscle degeneration is an important aspect of muscle regeneration. Satellite cells are believed to be the only myogenic stem cells in adult skeletal muscle and the source of regenerating muscle fibers. Upon activation, satellite cells proliferate, migrate to the site of degeneration, and become competent to fuse and differentiate. We show here that the transcription factor polyomavirus enhancer activator 3 (PEA3) is expressed in adult myoblasts in vitro when they are proliferative and during the early stages of differentiation. Overexpression of PEA3 accelerates differentiation, whereas blocking of PEA3 function delays myoblast fusion. PEA3 activates gene expression following binding to the ets motif most efficiently in conjunction with the transcription factor myocyte enhancer factor 2 (MEF2). In vivo, PEA3 is expressed in satellite cells only after muscle degeneration. Taken together, these results suggest that PEA3 is an important regulator of activated satellite cell function.
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Details
- Title
- A role for the ETS domain transcription factor PEA3 in myogenic differentiation
- Creators
- J M Taylor - Department of Medicine and Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock 72205, USAE E Dupont-Versteegden - Department of Medicine and Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock 72205, USAJ D Davies - Department of Medicine and Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock 72205, USAJ A Hassell - Department of Medicine and Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock 72205, USAJ D Houlé - Department of Medicine and Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock 72205, USAC M Gurley - Department of Medicine and Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock 72205, USAC A Peterson - Department of Medicine and Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock 72205, USA
- Publication Details
- Molecular and cellular biology, v 17(9), pp 5550-5558
- Publisher
- American Society for Microbiology (ASM)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1997XR72400063
- Scopus ID
- 2-s2.0-0030797552
- Other Identifier
- 991014877829004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology