Journal article
A selective human beta(3) adrenergic receptor agonist increases metabolic rate in rhesus monkeys
The Journal of clinical investigation, v 101(11), pp 2387-2393
01 Jun 1998
PMID: 9616210
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Activation of beta(3) adrenergic receptors on the surface of adipocytes leads to increases in intracellular cAMP and stimulation of lipolysis. In brown adipose tissue, this serves to upregulate and activate the mitochondrial uncoupling protein 1, which mediates a proton conductance pathway that uncouples oxidative phosphorylation, leading to a net increase in energy expenditure. While chronic treatment with beta(3) agonists in nonprimate species leads to uncoupling protein 1 up-regulation and weight loss, the relevance of this mechanism to energy metabolism in primates, which have much lower levels of brown adipose tissue, has been questioned. With the discovery of L-755,507, a potent and selective partial agonist for both human and rhesus beta(3) receptors, we now demonstrate that acute exposure of rhesus monkeys to a beta(3) agonist elicits lipolysis and metabolic rate elevation, and that chronic exposure increases uncoupling protein 1 expression in rhesus brown adipose tissue. These data suggest a role for beta(3) agonists in the treatment of human obesity.
Metrics
Details
- Title
- A selective human beta(3) adrenergic receptor agonist increases metabolic rate in rhesus monkeys
- Creators
- M H FisherA M AmendT J BachJ M BarkerE J BradyM R CandeloreD CarrollM A CascieriSHL ChiuL P DengM J ForrestB Hegarty-FriscinoX M GuanG J HomJ E HutchinsL J KellyR J MathvinkJ M MetzgerR R MillerH O OkE R ParmeeR SapersteinC D StraderR A StearnsG M ThompsonL TotaP P VicarioA E WeberJ W WoodsM J WyvrattP T ZafianD E MacIntyre
- Publication Details
- The Journal of clinical investigation, v 101(11), pp 2387-2393
- Publisher
- Rockefeller Univ Press
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Pharmacology and Physiology; Drexel University
- Web of Science ID
- WOS:000074165900011
- Scopus ID
- 2-s2.0-0032081279
- Other Identifier
- 991020111335104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Medicine, Research & Experimental