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Accepted (AM)Open Access (License Unspecified), Open
Journal article
A self-assembled peptide hydrogel for cytokine sequestration
Journal of materials chemistry. B, Materials for biology and medicine, Vol.8(5), pp.945-950
07 Feb 2020
PMID: 31919489
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cytokine-directed monocyte infiltration is involved in multiple pathological processes. Immuno-isolating matrices that can sequester cell-released chemokines in a microenvironment may prolong the viability and functionality of implanted materials. We describe a self-assembling peptide-based hydrogel that can capture the cytokine CCL2 released in the extracellular space by immune cells and stromal cells. The shear-responsive matrix can absorb and retain this signaling molecule needed for the chemotaxis of the infiltrating monocytes and their differentiation into phagocytic macrophages. Such cytokine-sequestering biomaterials may be useful as adjunctive materials with the delivery of exogenous implants or cell suspensions for tissue regeneration, without the administration of systemic immunosuppressants. Our work highlights the versatility of nanofibrous peptide hydrogels for modulating the biological response in tissue niches.
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Details
- Title
- A self-assembled peptide hydrogel for cytokine sequestration
- Creators
- Ka-Kyung Kim - New Jersey Institute of TechnologyZain Siddiqui - New Jersey Institute of TechnologyManali Patel - New Jersey Institute of TechnologyBiplab Sarkar - New Jersey Institute of TechnologyVivek A Kumar - New Jersey Institute of Technology
- Publication Details
- Journal of materials chemistry. B, Materials for biology and medicine, Vol.8(5), pp.945-950
- Publisher
- Royal Society of Chemistry
- Number of pages
- 6
- Grant note
- R15 EY029504 / NEI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Identifiers
- 991021956863104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Materials Science, Biomaterials