Journal article
A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortex
Proceedings of the National Academy of Sciences - PNAS, v 105(43), pp 16791-16796
28 Oct 2008
PMID: 18922773
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In the prefrontal cortex, NMDA receptors are important for normal prefrontal functions such as working memory, and their dysfunction plays a key role in the pathological processes of psychiatric disorders such as schizophrenia. Little is known, however, about the synaptic properties of NMDA receptors in the local circuits of recurrent excitation, a leading candidate mechanism underlying working memory. We investigated the NMDA receptor-mediated currents at monosynaptic connections between pairs of layer 5 pyramidal neurons. We found that NMDA receptor-mediated currents at prefrontal synapses in the adult, but not young, rats exhibit a twofold longer decay time-constant and temporally summate a train of stimuli more effectively, compared to those in the primary visual cortex. Experiments with pharmacological, immunocytochemical, and biochemical approaches further suggest that, in the adult animals, neurons express significantly more NR2B subunits in the prefrontal cortex than the visual cortex. The NR2B-rich synapses in the prefrontal circuitry may be critically implicated in online cognitive computations and plasticity in learning, as well as psychiatric disorders.
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Details
- Title
- A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortex
- Creators
- Huaixing Wang - Department of Neurobiology & Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USAGeorge G Stradtman, 3rdXiao-Jing WangWen-Jun Gao
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 105(43), pp 16791-16796
- Publisher
- PNAS; United States
- Grant note
- R21 MH079117-01A1 / NIMH NIH HHS MH232307 / NIMH NIH HHS R01 MH062349-07 / NIMH NIH HHS R01 MH085666 / NIMH NIH HHS R01 MH062349 / NIMH NIH HHS R21 MH079117 / NIMH NIH HHS R21 MH079117-02 / NIMH NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000260913500069
- Scopus ID
- 2-s2.0-55949099989
- Other Identifier
- 991014878412704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences