Journal article
A styrene-alt-maleic acid copolymer is an effective inhibitor of R5 and X4 human immunodeficiency virus type 1 infection
Journal of biomedicine & biotechnology, v 2010, 548749
2010
PMID: 20589074
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
An alternating copolymer of styrene and maleic acid (alt-PSMA) differs from other polyanionic antiviral agents in that the negative charges of alt-PSMA are provided by carboxylic acid groups instead of sulfate or sulfonate moieties. We hypothesized that alt-PSMA would have activity against human immunodeficiency virus type 1 (HIV-1) comparable to other polyanions, such as the related compound, poly(sodium 4-styrene sulfonate) (PSS). In assays using cell lines and primary immune cells, alt-PSMA was characterized by low cytotoxicity and effective inhibition of infection by HIV-1 BaL and IIIB as well as clinical isolates of subtypes A, B, and C. In mechanism of action assays, in which each compound was added to cells and subsequently removed prior to HIV-1 infection ("washout" assay), alt-PSMA caused no enhancement of infection, while PSS washout increased infection 70% above control levels. These studies demonstrate that alt-PSMA is an effective HIV-1 inhibitor with properties that warrant further investigation.
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Details
- Title
- A styrene-alt-maleic acid copolymer is an effective inhibitor of R5 and X4 human immunodeficiency virus type 1 infection
- Creators
- Vanessa Pirrone - Department of Microbiology and Immunology and Center for Molecular Therapeutics and Resistance, Drexel University College of Medicine, 245 N. 15th Street (MS1013A), Philadelphia, PA 19102, USAShendra PassicBrian WigdahlRobert F RandoMohamed LabibFred C Krebs
- Publication Details
- Journal of biomedicine & biotechnology, v 2010, 548749
- Publisher
- Wiley; United States
- Grant note
- U19 AI076965 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000279790600001
- Scopus ID
- 2-s2.0-77953495088
- Other Identifier
- 991014877887404721
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- Web of Science research areas
- Biotechnology & Applied Microbiology
- Medicine, Research & Experimental