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Journal article
A subpopulation of astrocyte progenitors defined by Sonic hedgehog signaling
Neural development, v 17(1), pp 2-2
14 Jan 2022
PMID: 35027088
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The molecular signaling pathway, Sonic hedgehog (Shh), is critical for the proper development of the central nervous system. The requirement for Shh signaling in neuronal and oligodendrocyte development in the developing embryo are well established. However, Shh activity is found in discrete subpopulations of astrocytes in the postnatal and adult brain. Whether Shh signaling plays a role in astrocyte development is not well understood.
Here, we use a genetic inducible fate mapping approach to mark and follow a population of glial progenitor cells expressing the Shh target gene, Gli1, in the neonatal and postnatal brain.
In the neonatal brain, Gli1-expressing cells are found in the dorsolateral corner of the subventricular zone (SVZ), a germinal zone harboring astrocyte progenitor cells. Our data show that these cells give rise to half of the cortical astrocyte population, demonstrating their substantial contribution to the cellular composition of the cortex. Further, these data suggest that the cortex harbors astrocytes from different lineages. Gli1 lineage astrocytes are distributed across all cortical layers, positioning them for broad influence over cortical circuits. Finally, we show that Shh activity recurs in mature astrocytes in a lineage-independent manner, suggesting cell-type dependent roles of the pathway in driving astrocyte development and function.
These data identify a novel role for Shh signaling in cortical astrocyte development and support a growing body of evidence pointing to astrocyte heterogeneity.
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Details
- Title
- A subpopulation of astrocyte progenitors defined by Sonic hedgehog signaling
- Creators
- Ellen C Gingrich - Stanford UniversityKendra Case - Drexel UniversityA Denise R Garcia - Drexel University
- Publication Details
- Neural development, v 17(1), pp 2-2
- Publisher
- Springer BMC
- Grant note
- R21 MH110724 / NIMH NIH HHS R01 NS096100 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000742354900001
- Scopus ID
- 2-s2.0-85123009558
- Other Identifier
- 991019168695004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Developmental Biology
- Neurosciences