Journal article
A subset of prostate basal cells lacks the expression of corresponding phenotypic markers
Pathology, research and practice, v 202(9), pp 651-662
2006
PMID: 16842934
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Immunohistochemical staining for cytokeratin (CK) 34
ßE12 has been routinely used to elucidate prostate basal cells for differentiation between non-invasive and invasive lesions. Our previous studies, however, revealed that some morphologically distinct basal cells observed on H&E-stained sections completely lacked CK34
ßE12 expression. Our current study attempted to assess whether these basal cells would also lack the expression of other phenotypic markers, and whether basal cell alterations would affect the proliferation status of the associated tumor cells. Consecutive sections from prostate tumors with large basal cell clusters that were morphologically distinct in H&E sections but were completely negative for CK 34
ßE12 were morphologically and immunohistochemically assessed with a panel of basal cell phenotypic and other markers. In addition to CK 34
ßE12, these basal cells also completely lacked the expression of other phenotypic markers, including CK5, CK14, p63, and maspin, in contrast to adjacent basal cells, which were strongly positive for these markers. Tumors surrounded by basal cell layers that lack the expression of basal cell phenotypic markers showed a significantly higher rate of cell proliferation and mast cell infiltration than their counterparts. These findings suggest that basal cells might be targets of a variety of pathological alterations, which could significantly impact biological presentations of associated tumor cells.
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Details
- Title
- A subset of prostate basal cells lacks the expression of corresponding phenotypic markers
- Creators
- Yan-gao Man - Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington DC 20306-6000, USA.Chengquan Zhao - Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, 6825 16th Street, NW 20306-6000, Washington DC, USAXiaoli Chen - Drexel University
- Publication Details
- Pathology, research and practice, v 202(9), pp 651-662
- Publisher
- Elsevier GmbH
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:000240730000003
- Scopus ID
- 2-s2.0-33747371224
- Other Identifier
- 991019167321404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pathology