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Accepted (AM)Open Access (License Unspecified), Open
Journal article
A systematic review and meta-analysis of sex differences in cannabis use disorder amongst people with comorbid mental illness
The American journal of drug and alcohol abuse, v 47(5), pp 535-547
03 Sep 2021
PMID: 34280058
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
While males are more likely diagnosed with cannabis use disorder (CUD), females are more susceptible to developing and maintaining CUD. Yet, for both sexes, CUD is associated with high rates of comorbid mental illness (MI).
To identify and compare sex differences in the prevalence of comorbid CUD amongst individuals with/without MIs.
This systematic review generated pooled odds ratios (OR) and 95% confidence intervals (CI) from 37 studies (including clinical trials, cohort, and case-control studies) among individuals with and without MIs, quantifying sex differences in rates of comorbid CUD. A meta-analysis was also completed.
In the CUD-only group, males were twice as likely to have CUD than females (OR = 2.0, CI = 1.9-2.1). Among MIs, males were more likely than females to have CUD comorbid with schizophrenia (OR ~2.6, CI = 2.5-2.7) and other psychotic, mood, and substance use disorders (1> OR <2.2, CI = 0.7-2.6). The reverse association (females > males) was observed for anxiety disorders and antisocial personality disorder (OR = 0.8, CI = 0.7-1.0). Among females, MIs increased the likelihood of having CUD, except for psychotic disorders and depression. A meta-analysis was inconclusive due to high heterogeneity across studies. Thus, comparisons across MI groups were not possible.
While males are more likely to be diagnosed with CUD, there are important sex differences in the prevalence of CUD across MI diagnoses that should be taken into account when approaching CUD prevention and determining treatment efficacy.
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Details
- Title
- A systematic review and meta-analysis of sex differences in cannabis use disorder amongst people with comorbid mental illness
- Creators
- Karolina Kozak - Centre for Addiction and Mental HealthPhilip H. Smith - Miami UniversityDarby J.E Lowe - Centre for Addiction and Mental HealthAndrea H. Weinberger - Albert Einstein College of MedicineZiva D Cooper - University of California, Los AngelesRachel A. Rabin - Douglas Mental Health University InstituteTony P. George - University of Toronto
- Publication Details
- The American journal of drug and alcohol abuse, v 47(5), pp 535-547
- Publisher
- Taylor & Francis
- Number of pages
- 13
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000674793800001
- Scopus ID
- 2-s2.0-85110772391
- Other Identifier
- 991022030932404721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Psychology, Clinical
- Substance Abuse