Journal article
A target definition based on electroanatomic maps for stereotactic arrhythmia radioablation
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, v 115, 103160
Nov 2023
PMID: 37847954
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose: Identifying the target region is critical for successfully treating ventricular tachycardia (VT) with single fraction stereotactic arrhythmia radioablation (STAR). We report the feasibility of target definition based on direct co-registration of electroanatomic maps (EAM) and radioablation planning images. Materials and methods: The EAM consists of 3D cardiac anatomy representation with electrical activity at endocardium and is acquired by a cardiac electrophysiologist (CEP) during electrophysiology study. The CEP generates an EAM using a 3D cardiac mapping system anticipating radioablation planning. Our in-house software read these non-DICOM EAMs, registered them to a planning image set, and converted them to DICOM structure files. The EAM based target volume was finalized based on a consensus of CEPs, radiation oncologists and medical physicists, then expanded to ITV and PTV. The simulation, planning, and treatment is performed with a standard STAR technique: a single fraction of 25 Gy using volumetric-modulated arc therapy or dynamic conformal arc therapy depending on the target shape. Results: Seven patients with refractory VT were treated by defining the target based on registering EAMs on the planning images. Dice similarity indices between reference map and reference contours after registration were 0.814 +/- 0.053 and 0.575 +/- 0.199 for LV and LA/RV, respectively. Conclusions: The quality of the transferred EAMs on the MR/CT images was sufficient to localize the treatment region. Five of 7 patients demonstrated a dramatic reduction in VT events after 6 weeks. Longer follow-up is required to determine the true safety and efficacy of this therapy using EAM-based direct registration method.
Metrics
Details
- Title
- A target definition based on electroanatomic maps for stereotactic arrhythmia radioablation
- Publication Details
- PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, v 115, 103160
- Publisher
- ELSEVIER SCI LTD; OXFORD
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:001094817900001
- Scopus ID
- 2-s2.0-85173668079
- Other Identifier
- 991021861167004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Radiology, Nuclear Medicine & Medical Imaging