Journal article
A unifying model of the role of the infralimbic cortex in extinction and habits
Learning & memory (Cold Spring Harbor, N.Y.), v 21(9), pp 441-448
Sep 2014
PMID: 25128534
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The infralimbic prefrontal cortex (IL) has been shown to be critical for the regulation of flexible behavior, but its precise function remains unclear. This region has been shown to be critical for the acquisition, consolidation, and expression of extinction learning, leading many to hypothesize that IL suppresses behavior as part of a "stop" network. However, this framework is at odds with IL function in habitual behavior in which the IL has been shown to be required for the expression and acquisition of ongoing habitual behavior. Here, we will review the current state of knowledge of IL anatomy and function in behavioral flexibility and provide a testable framework for a single IL mechanism underlying its function in both extinction and habit learning.
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Details
- Title
- A unifying model of the role of the infralimbic cortex in extinction and habits
- Creators
- Jacqueline M Barker - Medical University of South CarolinaJane R Taylor - Yale UniversityL Judson Chandler - Medical University of South Carolina
- Publication Details
- Learning & memory (Cold Spring Harbor, N.Y.), v 21(9), pp 441-448
- Publisher
- American Physical Society (APS)
- Number of pages
- 8
- Grant note
- P50 AA010761 / NIAAA NIH HHS DA011717 / NIDA NIH HHS AA020135 / NIAAA NIH HHS AA012870 / NIAAA NIH HHS AA010983 / NIAAA NIH HHS T32 AA007474 / NIAAA NIH HHS A007474 / PHS HHS AA010761 / NIAAA NIH HHS AA019967 / NIAAA NIH HHS DA015222 / NIDA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000341301200002
- Scopus ID
- 2-s2.0-84907777212
- Other Identifier
- 991020099895804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences
- Psychology, Experimental