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Journal article
ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort
Neurology, v 83(14), pp 1271-1276
30 Sep 2014
PMID: 25209581
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: To assess the relationships among ABO group, factor VIII (FVIII), and incident cognitive impairment in a large, prospective cohort study of black and white adults in the United States using a nested case-control design.
Methods: Incident cognitive impairment was defined using cognitive domain tests over a mean follow-up of 3.4 years. ABO blood group was measured by genotyping in a nested case-control sample of 495 cases with cognitive impairment and 587 controls.
Results: Those with blood group AB and those with higher FVIII had an increased risk of cognitive impairment, adjusting for age, race, region, and sex (respective odds ratios 1.82, 95% confidence interval [CI] 1.15-2.90; and 1.24, 95% CI 1.10-1.38 for 40 IU/dL higher FVIII). Mean FVIII was higher in those with blood type AB (142 IU/dL; 95% CI 119-165) compared with O (104 IU/dL; 95% CI 101-107), and FVIII mediated 18% of the association between AB group and incident cognitive impairment (95% CI for mediation 230% to 68%).
Conclusions: Blood group AB and higher FVIII were associated with increased incidence of cognitive impairment in this prospective study. The association of blood group AB with incident cognitive impairment was not significantly mediated by FVIII levels.
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Details
- Title
- ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort
- Creators
- Kristine S. Alexander - Indiana UniversityNeil A. Zakai - Indiana UniversitySarah Gillett - Indiana UniversityLeslie A. McClure - Indiana UniversityVirginia Wadley - Indiana UniversityFred Unverzagt - Indiana UniversityMary Cushman - Indiana University
- Publication Details
- Neurology, v 83(14), pp 1271-1276
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Grant note
- U01 NS041588 / National Institute of Neurological Disorders and Stroke (NINDS), NIH, Department of Health and Human Service T32HL007594-27 / National Heart, Lung and Blood Institute (NHLBI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) K08HL096841 / NHLBI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) K08HL096841 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) P30DK079626 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) U01NS041588 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000344860700014
- Scopus ID
- 2-s2.0-84921718607
- Other Identifier
- 991019231740304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology