Journal article
ADHD latent class clusters: DSM-IV subtypes and comorbidity
Psychiatry research, v 170(2-3)
30 Dec 2009
PMID: 19900717
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
ADHD (Attention Deficit Hyperactivity Disorder) has a complex. heterogeneous phenotype only partially captured by Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria. In this report, latent class analyses (LCA) are used to identify ADHD phenotypes using K-SADS-IVR (Schedule for Affective Disorders & Schizophrenia for School Age Children-IV-Revised) symptoms and symptom severity data from a clinical sample of 500 ADHD subjects, ages 6-18. participating in an ADHD genetic study. Results show that LCA identified six separate ADHD clusters, some corresponding to specific DSM-IV subtypes while others included several subtypes. DSM-IV comorbid anxiety and mood disorders were generally similar across all clusters, and subjects without comorbidity did not aggregate within any one cluster. Age and gender composition also varied. These results support findings from population-based LCA studies. The six clusters provide additional homogenous groups that can be used to define ADHD phenotypes in genetic association studies. The limited age ranges aggregating in the different clusters may prove to be a particular advantage in genetic studies where candidate gene expression may vary during developmental phases. DSM-IV comorbid mood and anxiety disorders also do not appear to increase cluster heterogeneity; however, longitudinal studies that cover period of risk are needed to support this finding. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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Details
- Title
- ADHD latent class clusters: DSM-IV subtypes and comorbidity
- Creators
- Josephine Elia - Children's Hospital of PhiladelphiaMauricio Arcos-Burgos - University of MiamiKelly L. Bolton - National Human Genome Research InstitutePaul J. Ambrosini - Drexel UniversityWade Berrettini - University of PennsylvaniaMaximilian Muenke - National Human Genome Research Institute
- Publication Details
- Psychiatry research, v 170(2-3)
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- K23MH066275-01 / NIMH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) NHGRI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) UL1-RR-024134 / CTR K23MH066275 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) ZIAHG000175 / NATIONAL HUMAN GENOME RESEARCH INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000272855200017
- Scopus ID
- 2-s2.0-70449526834
- Other Identifier
- 991019167776804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychiatry