Journal article
AGE-RELATED DIFFERENCES IN BIOMARKERS OF ACUTE INFLAMMATION DURING HOSPITALIZATION FOR SEPSIS
Shock (Augusta, Ga.), v 42(2), pp 99-107
Aug 2014
PMID: 24978893
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The authors aimed to evaluate age-related differences in inflammation biomarkers during the first 72 h of hospitalization for sepsis. This was a secondary analysis of a prospective observational cohort of adult patients (n = 855) from 10 urban academic emergency departments with confirmed infection and two or more systemic inflammatory response syndrome criteria. Six inflammation-related biomarkers were analyzed-chemokine (CC-motif) ligand-23, C-reactive protein, interleukin-1 receptor antagonist, neutrophil gelatinase-associated lipocalin (NGAL), peptidoglycan recognition protein, and tumor necrosis factor receptor-1a (TNFR-1a)-measured at presentation and 3, 6, 12, 24, 48, or 72 h later. The median age was 56 (interquartile range, 43 - 72) years, and sepsis severity was 38% sepsis, 16% severe sepsis without shock, and 46% septic shock; the overall 30-day mortality was 12%. Older age was associated with higher sepsis severity: 41% of subjects aged 18 to 34 years had severe sepsis or septic shock compared with 71% for those aged 65 years or older (P < 0.001). In longitudinal models adjusting for demographics, comorbidities, and infection source, older age was associated with higher baseline values for chemokine (CC-motif) ligand-23, interleukin-1 receptor antagonist, NGAL, and TNFR-1a (all P < 0.05). However, older adults had higher mean values during the entire 72-h period only for NGAL and TNFR-1a and higher final 72-h values only for TNFR-1a. Adjustment or stratification by sepsis severity did not change the age-inflammation associations. Although older adults had higher levels of inflammation at presentation and an increased incidence of severe sepsis and septic shock, these age-related differences in inflammation largely resolved during the first 72 h of hospitalization.
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Details
- Title
- AGE-RELATED DIFFERENCES IN BIOMARKERS OF ACUTE INFLAMMATION DURING HOSPITALIZATION FOR SEPSIS
- Creators
- Adit A. Ginde - College Station Medical CenterPatrick J. Blatchford - Biostat (United States)Stephen Trzeciak - Rowan UniversityJudd E. Hollander - College Station Medical CenterRobert Birkhahn - New York Methodist Hosp, Brooklyn, NY USARonny Otero - College Station Medical CenterTiffany M. Osborn - College Station Medical CenterEugene Moretti - Duke UniversityH. Bryant Nguyen - Loma Linda UniversityKyle J. Gunnerson - College Station Medical CenterDavid Milzman - Georgetown UniversityDavid F. Gaieski - College Station Medical CenterMunish Goyal - Georgetown UniversityCharles B. Cairns - College Station Medical CenterEmanuel P. Rivers - Wayne State UniversityNathan I. Shapiro - College Station Medical Center
- Publication Details
- Shock (Augusta, Ga.), v 42(2), pp 99-107
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 9
- Grant note
- Alere, Inc K23AG040708; R01HL091757 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000339245700004
- Scopus ID
- 2-s2.0-84904625822
- Other Identifier
- 991021448032504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Critical Care Medicine
- Hematology
- Peripheral Vascular Disease
- Surgery