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AGING MODELS OF ACUTE SEIZURES AND EPILEPSY
Journal article   Open access

AGING MODELS OF ACUTE SEIZURES AND EPILEPSY

Kevin M. Kelly
Epilepsy currents, v 10(1), pp 15-20
01 Jan 2010
DOI: https://doi.org/10.1111/j.1535-7511.2009.01341.x
PMID: 20126334
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1111/j.1535-7511.2009.01341.xView
Published, Version of Record (VoR)Open Access (License Unspecified),  Open

Abstract

Clinical Neurology Life Sciences & Biomedicine Neurosciences & Neurology Science & Technology
Aged animals have been used by researchers to better understand the differences between the young and the aged brain and how these differences may provide insight into the mechanisms of acute seizures and epilepsy in the elderly. To date, there have been relatively few studies dedicated to the modeling of acute seizures and epilepsy in aged, healthy animals. Inherent challenges to this area of research include the costs associated with the purchase and maintenance of older animals and, at times, the unexpected and potentially confounding comorbidities associated with aging. However, recent studies using a variety of in vivo and in vitro models of acute seizures and epilepsy in mice and rats have built upon early investigations in the field, all of which has provided an expanded vision of seizure generation and epileptogenesis in the aged brain. Results of these studies could potentially translate to new and tailored interventional approaches that limit or prevent the development of epilepsy in the elderly.

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Web of Science research areas
Clinical Neurology
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