Journal article
ALPHA1-PI FOR EMPHYSEMA DUE TO ALPHA1-ANTITRYPSIN DEFICIENCY
American family physician, v 40(3), pp 223-228
01 Sep 1989
PMID: 2672752
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Alpha 1-antitrypsin deficiency is a genetic disorder that may result in premature pulmonary emphysema. Affected persons are deficient in the protective protein, alpha 1-proteinase inhibitor (alpha 1-PI). The diagnosis should be considered in patients with signs of emphysema by age 40 (especially nonsmokers), those with predominantly lower lobe disease and those with a family history of premature emphysema. Recently, human alpha 1-PI has been purified and is available to prevent the development of disabling emphysema in affected individuals. Weekly infusion of the concentrate is effective in raising serum levels and is very safe, with only rare minor adverse effects.
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Details
- Title
- ALPHA1-PI FOR EMPHYSEMA DUE TO ALPHA1-ANTITRYPSIN DEFICIENCY
- Creators
- I D Horowitz - Drexel University, Hahnemann University (1982-1993)E S Schulman - Drexel University, Hahnemann University (1982-1993)
- Publication Details
- American family physician, v 40(3), pp 223-228
- Publisher
- Amer Acad Family Physicians
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pulmonary, Critical Care, and Sleep (Medicine)
- Web of Science ID
- WOS:A1989AN04300018
- Scopus ID
- 2-s2.0-0024449564
- Other Identifier
- 991019173686604721
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- Primary Health Care