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Accepted (AM)Open Access (License Unspecified), Open
Journal article
APOE Genotype Modifies the Relationship between Midlife Vascular Risk Factors and Later Cognitive Decline
Journal of stroke and cerebrovascular diseases, v 22(8), pp 1361-1369
01 Nov 2013
PMID: 23601373
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Vascular risk factors have been associated with cognitive decline; however, it remains unclear whether apolipoprotein E (APOE) genotype modifies this relationship. We aimed to further elucidate these relationships and extend previous findings by examining data from a more comprehensive cognitive assessment than used in prior studies.
In all, 1436 participants from the prospective Framingham Offspring Cohort Study underwent health examination from 1991 to 1995, followed by a baseline neuropsychological assessment (1999-2003) and a repeat neuropsychological assessment approximately 8 years later (2004-2009). Multivariate linear regression analyses were performed to examine the relationship among midlife vascular risk factors, presence of the APOE ε4 allele, and cognitive change.
APOE genotype significantly modified the associations between both midlife hypertension and cardiovascular disease and decline in language abilities and midlife diabetes and decline in verbal memory, attention, and visuospatial abilities. Associations between increased midlife vascular risk burden and greater cognitive decline were observed among APOE ε4 carriers but not noncarriers.
The present findings revealed a subgroup at increased risk for cognitive decline (APOE ε4 carriers with midlife exposure to vascular risk factors) and suggest that treatment of vascular risk factors during midlife may reduce the risk of cognitive impairment later in life, particularly among APOE ε4 carriers.
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Details
- Title
- APOE Genotype Modifies the Relationship between Midlife Vascular Risk Factors and Later Cognitive Decline
- Creators
- Katherine J. Bangen - University of California, San DiegoAlexa Beiser - Boston UniversityLisa Delano-Wood - University of California - San Diego School of MedicineDaniel A. Nation - VA San Diego Healthcare SystemMelissa Lamar - University of Illinois at ChicagoDavid J. Libon - Drexel UniversityMark W. Bondi - VA San Diego Healthcare SystemSudha Seshadri - Boston UniversityPhilip A. Wolf - Framingham Heart StudyRhoda Au - Framingham Heart Study
- Publication Details
- Journal of stroke and cerebrovascular diseases, v 22(8), pp 1361-1369
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- K24 AG26431, T32 MH 19934-17, P30 AG013846, R01 AG12674, AG08122, AG16495, AG033193, and AG031287 / National Institutes of Health N01-HC-25195 / NIH/NHLBI Framingham Heart Study's National Heart, Lung, and Blood Institute
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000327719000101
- Scopus ID
- 2-s2.0-84889074196
- Other Identifier
- 991021901012104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences
- Peripheral Vascular Disease