Journal article
APOSTEL-R Recommendations for Reporting Retinal Optical Coherence Tomography Studies in Rodents
Neurology : neuroimmunology & neuroinflammation, v 12(6), e200489
01 Nov 2025
PMID: 41061181
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Retinal optical coherence tomography (OCT) in rodent models has been used to longitudinally image retinal changes, to define end points for more costly or time-consuming experiments, and to better understand the pathophysiology underlying OCT findings in human diseases. No standardization of rodent OCT reporting currently exists. Here, we aim to establish consensus recommendation for reporting results from retinal OCT studies in rodents.
Initial recommendations were developed based on the APOSTEL criteria for quantitative OCT reporting in humans by a core team. Using a modified Delphi process, an expert panel of rodent OCT researchers (N = 31) and the wider scientific community discussed, refined, and voted on these initial recommendations. The list of recommendations was then revised and approved by the expert panel.
The final 7-point checklist includes reporting recommendations regarding the study protocol, OCT device, acquisition settings and modifications, scanning protocol, funduscopic imaging, postacquisition data selection and image data analyses, and qualitative and quantitative results. With a median agreement score of 3 or 4 out of 4, the scientific community agreed with these recommendations. After revisions, the expert panel accepted the final recommendations.
The Advised Protocol for OCT Study Terminology and Elements for reporting OCT studies in rodents (APOSTEL-R) originates from an expert consensus. They will provide guidance throughout the experimental process and will contribute to the standardization and quality improvement of preclinical OCT studies.
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Details
- Title
- APOSTEL-R Recommendations for Reporting Retinal Optical Coherence Tomography Studies in Rodents
- Creators
- Frederike Cosima Oertel - Humboldt-Universität zu BerlinDelia Cabrera Debuc - University of MiamiPeter A Calabresi - Johns Hopkins UniversityMei Chen - Queen's University BelfastChristian Cordano - University of California, San FranciscoMichael Dietrich - Düsseldorf University HospitalNicolas Feltgen - University Hospital of BaselOliver Gramlich - University of IowaAri J Green - University of California, San FranciscoJanos Groh - German Center for Neurodegenerative DiseasesSu-Chun Huang - Department of Neurology, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genova, ItalyBenjamin Knier - München Klinik SchwabingThomas Korn - Munich Cluster for Systems NeurologyLetizia Leocani - Vita-Salute San Raffaele UniversityAnat Loewenstein - Tel Aviv UniversityChristian van Oterendorp - Universitätsmedizin GöttingenTunde Peto - Queen's University BelfastSven Schippling - University Hospital ZurichLeopold Schmetterer - Statistics AustriaSteffen Schmitz-Valckenberg - University of BonnMathias W Seeliger - STZ eyetrialKenneth S Shindler - Penn Presbyterian Medical CenterJoel S Schuman - Drexel UniversityMustafa Sindi - Düsseldorf University HospitalAdnan Tufail - MRC Prion UnitJui-Kai Wang - The University of Texas Southwestern Medical CenterSebastian Wolf - University Hospital of BernYuyi You - Ingham InstituteMartin Zinkernagel - University Hospital of BernWolf Lagrèze - University Medical Center FreiburgPhilipp Albrecht - Düsseldorf University HospitalIMSVISUAL consortium
- Publication Details
- Neurology : neuroimmunology & neuroinflammation, v 12(6), e200489
- Publisher
- American Academy of Neurology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering and Science
- Web of Science ID
- WOS:001589795400001
- Scopus ID
- 2-s2.0-105018285563
- Other Identifier
- 991022197424204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences