Journal article
ATRP under Biologically Relevant Conditions: Grafting from a Protein
ACS macro letters, v 1(1), pp 6-10
17 Jan 2012
PMID: 35578470
Abstract
Atom transfer radical polymerization (ATRP) methods were developed in water-based media, to grow polymers from proteins under biologically relevant conditions. These conditions gave good control over the resulting polymer, while still preserving the native structure. Several reaction parameters, such as ligand structure, halide species, and initiation mode were optimized in water and pas buffer to yield well-defined polymers grown from bovine serum albumin (BSA), functionalized with cleavable ATRP initiators (I). The CuCl complex with ligand 2,2'-bipyridyne (bpy) provides the best conditions for the polymerization of oligo(ethylene oxide) Methacrylate (OEOMA) in water at 30 degrees C under normal. ATRP conditions (I/CuCl/CuCl2/bpy = 1/1/9/22), while the CuBr/bpy complex gave better performance in PBS. Activators generated by electron transfer (AGET) ATRP gave well-controlled polymerization of OEOMA at 30 degrees C with the ligand tris(2-pyridylmethyl)amine (TPMA), (I/CuBr2/TpMA = 1/10/11). The AGET ATRP reactions required slow feeding of a very small amount of ascorbic acid into the aqueous reaction medium or buffer. The reaction conditions developed were used to create a smart, thermoresponsive, protein-polymer, hybrid.
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Details
- Title
- ATRP under Biologically Relevant Conditions: Grafting from a Protein
- Creators
- Saadyah Averick - Carnegie Mellon UniversityAntonina Simakova - Carnegie Mellon UniversitySangwoo Park - Carnegie Mellon UniversityDominik Konkolewicz - Carnegie Mellon UniversityAndrew J. D. Magenau - Carnegie Mellon UniversityRyan A. Mehl - Franklin & Marshall CollegeKrzysztof Matyjaszewski - Carnegie Mellon University
- Publication Details
- ACS macro letters, v 1(1), pp 6-10
- Publisher
- American Chemical Society; Washington, DC
- Number of pages
- 5
- Grant note
- CHE-0130903; CHE-1039870; CHE-9808188 / NSF; National Science Foundation (NSF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering; Neurosurgery
- Web of Science ID
- WOS:000301913800003
- Scopus ID
- 2-s2.0-84861349836
- Other Identifier
- 991020531846704721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Polymer Science