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ATRP under Biologically Relevant Conditions: Grafting from a Protein
Journal article

ATRP under Biologically Relevant Conditions: Grafting from a Protein

Saadyah Averick, Antonina Simakova, Sangwoo Park, Dominik Konkolewicz, Andrew J. D. Magenau, Ryan A. Mehl and Krzysztof Matyjaszewski
ACS macro letters, v 1(1), pp 6-10
17 Jan 2012
DOI: https://doi.org/10.1021/mz200020c
PMID: 35578470

Abstract

Physical Sciences Polymer Science Science & Technology
Atom transfer radical polymerization (ATRP) methods were developed in water-based media, to grow polymers from proteins under biologically relevant conditions. These conditions gave good control over the resulting polymer, while still preserving the native structure. Several reaction parameters, such as ligand structure, halide species, and initiation mode were optimized in water and pas buffer to yield well-defined polymers grown from bovine serum albumin (BSA), functionalized with cleavable ATRP initiators (I). The CuCl complex with ligand 2,2'-bipyridyne (bpy) provides the best conditions for the polymerization of oligo(ethylene oxide) Methacrylate (OEOMA) in water at 30 degrees C under normal. ATRP conditions (I/CuCl/CuCl2/bpy = 1/1/9/22), while the CuBr/bpy complex gave better performance in PBS. Activators generated by electron transfer (AGET) ATRP gave well-controlled polymerization of OEOMA at 30 degrees C with the ligand tris(2-pyridylmethyl)amine (TPMA), (I/CuBr2/TpMA = 1/10/11). The AGET ATRP reactions required slow feeding of a very small amount of ascorbic acid into the aqueous reaction medium or buffer. The reaction conditions developed were used to create a smart, thermoresponsive, protein-polymer, hybrid.

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Domestic collaboration
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Polymer Science
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