Journal article
Abdominal Vagotomy Blocks the Satiety Effect of Cholecystokinin in the Rat
Science (American Association for the Advancement of Science), v 213(4511), pp 1036-1037
28 Aug 1981
PMID: 7268408
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The site where peripherally administered cholecystokinin-8 elicits satiety was investigated by injecting rats with cholecystokinin-8 (1 to 8 micrograms per kilogram of body weight, intraperitoneally) after they had received bilateral lesions of the ventromedial hypothalamus or after they had undergone bilateral abdominal vagotomy or selective vagotomies. Abdominal vagotomy or gastric vagotomy abolished or reduced the satiety effect of cholecystokinin, but lesions of the ventromedial hypothalamus did not. These results demonstrate that peripherally administered cholecystokinin acts in the abdomen through gastric vagal fibers and not directly on the brain to produce satiety in the rat.
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Details
- Title
- Abdominal Vagotomy Blocks the Satiety Effect of Cholecystokinin in the Rat
- Creators
- G. P. Smith - NewYork–Presbyterian HospitalC. Jerome - NewYork–Presbyterian HospitalB. J. Cushin - NewYork–Presbyterian HospitalR. Eterno - NewYork–Presbyterian HospitalK. J. Simansky - NewYork–Presbyterian Hospital
- Publication Details
- Science (American Association for the Advancement of Science), v 213(4511), pp 1036-1037
- Publisher
- American Association for the Advancement of Science (AAAS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- SOM Dean - Research Administration
- Web of Science ID
- WOS:A1981MC22800042
- Scopus ID
- 2-s2.0-0019890231
- Other Identifier
- 991021842530604721
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