Journal article
Abdominal vagotomy dissociates the anorectic mechanisms for peripheral serotonin and cholecystokinin
American journal of physiology. Regulatory, integrative and comparative physiology, v 265(3), pp R602-R608
01 Sep 1993
PMID: 8214153
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
These studies compared the effects of total abdominal vagotomy (VGX) on ingestive actions produced by peripheral serotonergic and cholecystokinergic (CCKergic) stimulation in rats. Subcutaneous injection of 0.01-0.16 mumol/kg of the serotonin (5-HT) analogue 5-carboxamidotryptamine (5-CT) dose-dependently reduced mash intake equally in VGX rats and their laparotomized (LAP) controls but concurrently stimulated drinking only in the controls. The sulfated octapeptide of cholecystokinin (CCK-8, 4.0 nmol/kg ip) also reduced food intake only in the controls. In a second set of rats, vagotomy did not alter anorexia after intraperitoneal administration of either 2.0 or 8.0 mumol/kg of 5-HT or of 0.03 mumol/kg of 5-CT but abolished anorexia after a large dose of CCK-8 (8.0 nmol/kg). The completeness of vagotomy was verified histologically by immunohistochemical staining of the vagal bundles for the high molecular weight form of neurofilament-H protein. We report for the first time that 5-CT produces anorexia by a vagally independent mechanism. In contrast, 5-CT stimulates drinking by a pathway that does involve vagal function. Finally, we confirm the prediction that vagotomy dissociates the neural mechanisms for the anorectic action of peripheral 5-HTergic and CCKergic stimulation.
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Details
- Title
- Abdominal vagotomy dissociates the anorectic mechanisms for peripheral serotonin and cholecystokinin
- Creators
- K Eberle-Wang - Department of Pharmacology, Medical College, of Pennsylvania, Eastern Pennsylvania Psychiatric Institute, Philadelphia 19129P Levitt - Department of Pharmacology, Medical College, of Pennsylvania, Eastern Pennsylvania Psychiatric Institute, Philadelphia 19129K. J Simansky - Department of Pharmacology, Medical College, of Pennsylvania, Eastern Pennsylvania Psychiatric Institute, Philadelphia 19129
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, v 265(3), pp R602-R608
- Publisher
- American Physiological Society (APS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1993MA18600059
- Scopus ID
- 2-s2.0-0027362025
- Other Identifier
- 991014877904204721
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- Web of Science research areas
- Physiology