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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Aberrant mTOR activation in senescence and aging: A mitochondrial stress response?
Experimental gerontology, v 68
Aug 2015
PMID: 25449851
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Unexpected activation of mTOR signaling, measured by ribosomal S6 phosphorylation or ribosomal S6 kinase (p70S6K) activity, has been reported in aging-related settings. Evidence of elevated mTOR activity has been reported in the heart and muscle tissue in aged mice and humans, mouse models of progeria, and senescent human fibroblasts. We explore these reports and the possibility that activation of the mTOR/p70S6K kinase pathway may represent a ROS-mediated response to mitochondrial stress leading to the activation of senescence. This activation is a hallmark of both aged tissue and senescent human cells.
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Details
- Title
- Aberrant mTOR activation in senescence and aging: A mitochondrial stress response?
- Creators
- Timothy Nacarelli - Drexel UniversityAshley Azar - Drexel UniversityChristian Sell - Drexel University
- Publication Details
- Experimental gerontology, v 68
- Publisher
- Elsevier
- Grant note
- R01 AG022443 / NIA NIH HHS AG39733 / NIA NIH HHS R21 AG039799 / NIA NIH HHS AG22443 / NIA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000355835100012
- Scopus ID
- 2-s2.0-84941272088
- Other Identifier
- 991019168688804721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Geriatrics & Gerontology