Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Aberrant maturation and connectivity of prefrontal cortex in schizophrenia-contribution of NMDA receptor development and hypofunction
Molecular psychiatry, v 27(1), pp 731-743
Jan 2022
PMID: 34163013
Abstract
The neurobiology of schizophrenia involves multiple facets of pathophysiology, ranging from its genetic basis over changes in neurochemistry and neurophysiology, to the systemic level of neural circuits. Although the precise mechanisms associated with the neuropathophysiology remain elusive, one essential aspect is the aberrant maturation and connectivity of the prefrontal cortex that leads to complex symptoms in various stages of the disease. Here, we focus on how early developmental dysfunction, especially N-methyl-D-aspartate receptor (NMDAR) development and hypofunction, may lead to the dysfunction of both local circuitry within the prefrontal cortex and its long-range connectivity. More specifically, we will focus on an "all roads lead to Rome" hypothesis, i.e., how NMDAR hypofunction during development acts as a convergence point and leads to local gamma-aminobutyric acid (GABA) deficits and input-output dysconnectivity in the prefrontal cortex, which eventually induce cognitive and social deficits. Many outstanding questions and hypothetical mechanisms are listed for future investigations of this intriguing hypothesis that may lead to a better understanding of the aberrant maturation and connectivity associated with the prefrontal cortex.
Metrics
Details
- Title
- Aberrant maturation and connectivity of prefrontal cortex in schizophrenia-contribution of NMDA receptor development and hypofunction
- Creators
- Wen-Jun Gao - Drexel UniversitySha-Sha Yang - Drexel UniversityNancy R Mack - Drexel UniversityLinda A Chamberlin - Drexel University
- Publication Details
- Molecular psychiatry, v 27(1), pp 731-743
- Publisher
- Springer Nature
- Grant note
- R21 MH097623 / NIMH NIH HHS R21 MH121836 / NIMH NIH HHS R21 MH110678 / NIMH NIH HHS R01 MH085666 / NIMH NIH HHS P50 MH068789 / NIMH NIH HHS R21 MH079117 / NIMH NIH HHS R21 MH111609 / NIMH NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000664810000001
- Scopus ID
- 2-s2.0-85108849787
- Other Identifier
- 991019167444004721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Neurosciences
- Psychiatry