Journal article
Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus
Proceedings of the National Academy of Sciences - PNAS, v 103(46), pp 17501-17506
06 Nov 2006
PMID: 17088541
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Although hippocampal neurogenesis has been described in many adult mammals, the functional impact of this process on physiology and behavior remains unclear. In the present study, we used two independent methods to ablate hippocampal neurogenesis and found that each procedure caused a limited behavioral deficit and a loss of synaptic plasticity within the dentate gyrus. Specifically, focal X irradiation of the hippocampus or genetic ablation of glial fibrillary acidic protein-positive neural progenitor cells impaired contextual fear conditioning but not cued conditioning. Hippocampal-dependent spatial learning tasks such as the Morris water maze and Y maze were unaffected. These findings show that adult-born neurons make a distinct contribution to some but not all hippocampal functions. In a parallel set of experiments, we show that long-term potentiation elicited in the dentate gyrus in the absence of GABA blockers requires the presence of new neurons, as it is eliminated by each of our ablation procedures. These data show that new hippocampal neurons can be preferentially recruited over mature granule cells
in vitro
and may provide a framework for how this small cell population can influence behavior.
Metrics
Details
- Title
- Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus
- Creators
- Michael D. Saxe - Columbia UniversityFortunato Battaglia - Columbia UniversityJing-Wen Wang - Columbia UniversityGael Malleret - Columbia UniversityDenis J. David - Columbia UniversityJames E. Monckton - Columbia UniversityA. Denise R. Garcia - University of California, Los AngelesMichael V. Sofroniew - University of California at Los AngelesEric R. Kandel - Columbia UniversityLuca Santarelli - Columbia UniversityRené Hen - Columbia UniversityMichael R. Drew - Center For Neurobiology and Behavior
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 103(46), pp 17501-17506
- Publisher
- National Academy of Sciences
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; College of Arts and Sciences; Drexel University
- Web of Science ID
- WOS:000242249400078
- Scopus ID
- 2-s2.0-33751213392
- Other Identifier
- 991020099209204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences