Journal article
Abnormal spontaneous potentials in distal muscles in animal models of spinal cord injury
Muscle & nerve, v 31(1)
Jan 2005
PMID: 15508125
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Spontaneous potentials in skeletal muscle distal to human spinal cord injury (SCI) have been reported in the literature. Two animal models of SCI were studied for the presence of similar potentials. Six rats and two cats with surgical transections of the thoracic spinal cord were followed for 4-6 weeks with serial electromyography. As a control for the effects of anesthesia and serial testing, three intact rats were anesthetized and tested weekly for 4 weeks. In rats with spinal cord transection, spontaneous potentials emerged 4-7 days after surgery and persisted for the duration of the study (28-32 days). Spontaneous potentials were absent in controls at all timepoints. In cats, spontaneous potentials were observed 8 days postinjury and gradually diminished, starting at 2 weeks. Spontaneous potentials therefore occur after SCI in animals as well as in humans. The utilization of animal models will facilitate the understanding of alterations that occur distal to spinal cord lesions and affect the function of lower motor neurons, leading to peripheral denervation after SCI.
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Details
- Title
- Abnormal spontaneous potentials in distal muscles in animal models of spinal cord injury
- Creators
- Anthony S Burns - Thomas Jefferson UniversityMichel A Lemay - Drexel UniversityAlan Tessler - Drexel University
- Publication Details
- Muscle & nerve, v 31(1)
- Publisher
- Wiley
- Number of pages
- 6
- Grant note
- 2K12 HD0197-6 / NICHD NIH HHS NS41975 / NINDS NIH HHS NS24707 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000226015600008
- Scopus ID
- 2-s2.0-11144228709
- Other Identifier
- 991019168148004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences