Journal article
Abrasion-resistant bioelectronics based on a three-dimensional topological architecture and covalent chemical anchoring
Nature electronics, Forthcoming
04 May 2026
Featured in Collection : Drexel's Newest Publications
Abstract
Integrating electronics with biological systems could be of use in the monitoring of human health and the treatment of diseases. However, dynamic body movements exert stress and induce micromotions at the interface between a substrate and functional layers. This often leads to device disintegration and failure, and hampers long-term utility and reliability. Here we report abrasion-resistant bioelectronics based on a three-dimensional topological interpenetrating architecture that is reinforced with covalent chemical anchoring. The approach, which we term TopoLock, is applicable to a range of bioelectronic materials and fabrication technologies. In multiple preclinical animal models, we show that this system can be used for long-term electrophysiological recording, electrical stimulation and electrochemical sensing at challenging anatomical locations that experience continuous mechanical stresses.
Metrics
1 Record Views
Details
- Title
- Abrasion-resistant bioelectronics based on a three-dimensional topological architecture and covalent chemical anchoring
- Creators
- Yewei Huang - University of PennsylvaniaLiangpeng Chen - Capital Medical UniversityJian-Cheng Lai - Stanford UniversityBowen Cao - University of PennsylvaniaYuhui Wang - University of PennsylvaniaZitong Xu - University of PennsylvaniaYuhang Ye - University of PennsylvaniaTianyu Cai - University of PennsylvaniaZiyang Li - Capital Medical UniversityLingyi Bi - Drexel UniversityBenjamin Chacon - Drexel UniversityWang Jia - Capital Medical UniversityYury Gogotsi - Drexel UniversityDeling Li (Corresponding Author) - Capital Medical UniversityYuanwen Jiang (Corresponding Author) - University of Pennsylvania
- Publication Details
- Nature electronics, Forthcoming
- Publisher
- Nature Publishing
- Number of pages
- 18
- Grant note
- Center for Precision Engineering for Health (CPE4H) from the University of Pennsylvania NNCI-2025608 / NSF National Nanotechnology Coordinated Infrastructure Program P30 AR069619 / Penn Center for Musculoskeletal Disorders Histology Core
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering; A.J. Drexel Nanomaterials Institute
- Web of Science ID
- WOS:001755387100001
- Other Identifier
- 991022179503604721