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Absence of rapid sensory adaptation in neocortex during information processing states
Journal article   Open access   Peer reviewed

Absence of rapid sensory adaptation in neocortex during information processing states

Manuel A Castro-Alamancos
Neuron (Cambridge, Mass.), v 41(3), pp 455-464
05 Feb 2004
PMID: 14766183
url
https://doi.org/10.1016/s0896-6273(03)00853-5View
Published, Version of Record (VoR) Open

Abstract

Adaptation, Physiological - physiology Anesthesia Animals Avoidance Learning - physiology Behavior, Animal Cerebral Cortex - physiology Conditioning, Psychological Dose-Response Relationship, Radiation Electric Stimulation Evoked Potentials Immobilization - physiology Inhibition, Psychological Motor Activity Neocortex - physiology Physical Stimulation Rats Rats, Sprague-Dawley Reaction Time Sleep - physiology Time Factors Vibrissae - innervation Vibrissae - physiology Wakefulness - physiology
One prominent feature of sensory responses in neocortex is that they rapidly adapt to increases in frequency, a process called "sensory adaptation." Here we show that sensory adaptation mainly occurs during quiescent states such as anesthesia, slow-wave sleep, and awake immobility. In contrast, during behavior-ally activated states, sensory responses are already adapted. For instance, during learning of a behavioral task, when an animal is very alert and expectant, sensory adaptation is mostly absent. After learning occurs, and the task becomes routine, the level of alertness lessens and sensory adaptation becomes robust. The primary sensory thalamocortical pathway of alert and expectant animals is in the adapted state, which may be required for adequate sensory information processing.

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