Journal article
Abstract 12350: The Associations of Psychosocial Stressors and Coronary Heart Disease
Circulation (New York, N.Y.), v 140(Suppl_1 Suppl 1), pp A12350-A12350
19 Nov 2019
Abstract
IntroductionThe overall association between psychosocial stress and cardiovascular disease is stronger in women and the strength of this association may vary by type of stressor. In this study, we assessed whether job strain, stressful life events and social strain are associated with a higher incidence of coronary heart disease (CHD) in women.MethodsWe used data from 80,825 Women’s Health Initiative Observational Study participants aged 50-79 years old at baseline. Participants were followed for an average of 14.7 years. We assessed job strain through linkage of Standard Occupational Classification codes to the Occupational Information Network. Stressful life events and social strain were measured via validated self-reported questionnaires. We used cox proportional hazard models to evaluate associations of each stressor with CHD separately and jointly.ResultsAfter adjustment for age and other stressors, higher job strain was associated with a 13% increased risk of CHD (HR=1.13, 95% CI1.03, 1.24). CHD risk increased by 20% for women with high life event scores (HR=1.20, 95% CI1.09, 1.31) and by 12% for women with high social strain (HR=1.12, 95% CI1.04, 1.22). The increased risk was attenuated after adjustment for traditional CHD risk factors, indicating they may be on the pathway between stressors and CHD. Additionally, we found a significant interaction between job strain and social strain (P value= 0.02). Among women with high social strain, high job strain was associated with a 25% increased risk of CHD (HR=1.25, 95% CI1.07, 1.46) compared to those with low job strain.ConclusionsHigh job strain, stressful life events and social strain were each associated with higher CHD risk. Job strain and social strain may work synergistically and lead to an additional increase in CHD risk. Further studies should explore potentially mechanisms underlying different stressors, traditional risk factors and CHD.
Metrics
6 Record Views
Details
- Title
- Abstract 12350: The Associations of Psychosocial Stressors and Coronary Heart Disease
- Creators
- Conglong Wang - Sch of Public Health Dept of Epidemiology and Biostatistics, Drexel Univ, Philadelphia, PAFélice Lê-Scherban - Drexel UniversityJennifer Taylor - Drexel UniversityElena Salmoirago-blotcher - Miriam Hosp, Brown Med Sch, Providence, RIMatthew Allison - Univ of California San Diego, La Jolla, CAGefen David - LeBow College of Business, Drexel Univ, Philadelphia, PALucy Robinson - Drexel UniversityYvonne Michael - Drexel University
- Publication Details
- Circulation (New York, N.Y.), v 140(Suppl_1 Suppl 1), pp A12350-A12350
- Publisher
- by the American College of Cardiology Foundation and the American Heart Association, Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Decision Sciences (and Management Information Systems); Urban Health Collaborative; Epidemiology and Biostatistics; Environmental and Occupational Health
- Other Identifier
- 991019205549204721