Journal article
Abstract 12700: Sex Differences in Risk Factors for Incident Atrial Fibrillation: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study
Circulation (New York, N.Y.), Vol.138(Suppl_1 Suppl 1), pp.A12700-A12700
06 Nov 2018
Abstract
BackgroundWomen are less likely to develop atrial fibrillation (AF) compared with men. It is unclear if this is related to difference in risk factors leading to AF or due to a differential impact of the same risk factors between sexes.MethodsThis analysis included 11,806 participants (55.2 % women) free of AF at baseline from the REGARDS study. Incident AF was ascertained by study-scheduled electrocardiograms and self-reported history at a follow-up examination. Logistic regression was used to examine baseline associations with incident AF. Backwards elimination logistic regression was used to identify AF risk factors in men and women, separately.ResultsOver a median follow-up of 9.0 years, 588 (11.1%) men and 428 (6.6%) women (p-value <0.001) developed AF. Men had a higher risk of AF than women in a logistic regression model adjusted for age and race [OR (95%CI)1.61(1.26, 1.75)]. Age, white race, height, weight, use of blood pressure lowering medications and history of cardiovascular disease were identified by backward elimination as AF risk factors shared by both sexes. On the other hand, diabetes was an AF risk factor in women but not in men (Table). Among the shared risk factors between men and women, only age showed a stronger association in women than in men [Interaction p-value=0.003]. Adjustment for the shared risk factors eliminated the sex difference in AF risk [OR (95%CI)0.90 (0.74, 1.09)], which was more noticeable in those younger than the median age (62 years) compared to those who were older [interaction p-value 0.003].ConclusionsWomen and men share several AF risk factors, and these shared risk factors explain the sex differences. However, age association with AF differs by sex, and age modifies the associations between sex and other AF risk factors.
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Details
- Title
- Abstract 12700: Sex Differences in Risk Factors for Incident Atrial Fibrillation: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study
- Creators
- Abhishek Bose - Section on Hosp Medicine, Wake Forest Baptist Health, Winston Salem, NCWesley O’Neal - Div of Cardiology, Emory Univ Sch of Medicine, Atlanta, GAChengyi Wu - Dornsife Sch of Public Health, Drexel Univ, Philadelphia, PALeslie McClure - Drexel UniversitySuzanne Judd - Sch of Public Health, Univ of Alabama, Birmingham, ALVirginia Howard - Sch of Public Health, Univ of Alabama, Birmingham, ALGeorge Howard - Sch of Public Health, Univ of Alabama, Birmingham, ALElsayed Soliman - Dept of Epidemiology and Prevention, Wake Forest Sch of Medicine, Winston Salem, NC
- Publication Details
- Circulation (New York, N.Y.), Vol.138(Suppl_1 Suppl 1), pp.A12700-A12700
- Publisher
- by the American College of Cardiology Foundation and the American Heart Association, Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Identifiers
- 991019170460604721