Journal article
Abstract 15021: Modern Prevalence of Fredrickson-Levy-Lees Type III Hyperlipoproteinemia: Findings From the Very Large Database of Lipids and National Health and Nutrition Examination Survey
Circulation (New York, N.Y.), v 140(Suppl_1 Suppl 1), pp A15021-A15021
19 Nov 2019
Abstract
IntroductionDysbetalipoproteinaemia (HLP3) is a genetic disorder of excess lipoprotein remnants that powerfully promotes premature atherogenic cardiovascular disease. Prior smaller studies using electrophoresis and ultracentrifugation (UC) estimated a prevalence of 0.1-0.4%.HypothesisWe hypothesized that current prevalence of HLP3 in U.S. adults with a newly described apolipoprotein B (apoB) method may be higher than prior estimates.MethodsWe performed cross-sectional analysis of 128,485 U.S. adults from the Very Large Database of Lipids (VLDbL) using two algorithms to diagnose HLP3Vertical Auto Profile UC and apoB methods. We evaluated 4,926 participants from the 2011-2014 National Health and Nutrition Examination Survey (NHANES) with the apoB method. We examined demographic and lipid characteristics stratified by presence of HLP3 and evaluated lipid characteristics in those with HLP3 phenotype discordance and concordance as determined by apoB and UC methods.ResultsIn VLDbL and NHANES, a 1.7-2.0% HLP3 prevalence was observed with the apoB method as compared to a 0.2% prevalence with the UC method. HLP3 participants had higher very low density lipoprotein cholesterol and TG in addition to lower apoB and low density cholesterol than other participants across apoB and UC methods in VLDLbL and NHANES (p>/=0.015). Participants who were both apoB and UC method HLP3 positive had higher very low density lipoprotein and intermediate density lipoprotein cholesterol as well as more elevated TG/apoB and total cholesterol/apoB ratios (all p<0.001) than those who were apoB method positive and UC method negative.ConclusionHLP3 may be more prevalent than historically and clinically appreciated. The apoB method increases HLP3 identification via inclusion of milder phenotypes. Further work should evaluate the clinical implications of HLP3 diagnosis at various lipid algorithm cut-points to evaluate the ideal diagnostic standard in the modern era.
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Details
- Title
- Abstract 15021: Modern Prevalence of Fredrickson-Levy-Lees Type III Hyperlipoproteinemia: Findings From the Very Large Database of Lipids and National Health and Nutrition Examination Survey
- Creators
- Vincent Pallazola - Johns Hopkins UniversityVasanth Sathiyakumar - Cardiology, Johns Hopkins Hosp, Baltimore, MDJihwan Park - Johns Hopkins UniversityRachit Vakil - Johns Hopkins Hosp, Baltimore, MDPeter Toth - College Station Medical CenterMariana Lazo-Elizondo - Johns Hopkins UniversityEmily Brown - Johns Hopkins UniversityRenato Quispe - The Bronx DefendersEliseo Guallar - Johns Hopkins UniversityRoger Blumenthal - Johns Hopkins Hosp, Baltimore, MDSteven Jones - Johns Hopkins UniversityDavid Marais - University of Cape TownDaniel Soffer - University of PennsylvaniaAllan Sniderman - Royal Victoria Hosp, Montreal, CanadaSeth Martin - Johns Hopkins Hosp, Baltimore, MD
- Publication Details
- Circulation (New York, N.Y.), v 140(Suppl_1 Suppl 1), pp A15021-A15021
- Publisher
- by the American College of Cardiology Foundation and the American Heart Association, Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Other Identifier
- 991020550497504721