Journal article
Abstract P009: The Association of Liver Enzymes with Subclinical Myocardial Damage
Circulation (New York, N.Y.), v 125(suppl_10)
13 Mar 2012
Abstract
Background:
Nonalcoholic fatty liver disease (NAFLD) is present in up to 30% of the US population and is strongly associated with obesity and diabetes. While a number of studies support an association between NAFLD and cardiovascular disease, limited evidence exists for the association with subclinical myocardial injury.
Objective:
To test the hypothesis that elevated liver enzymes (Alanine aminotrasferase [ALT], Aspartate aminotranferase [AST] and Gamma-glutamyl transpeptidase [GGT]) in the absence of significant alcohol consumption are independently associated with subclinical myocardial injury, defined by elevated cardiac troponin-T measured using a highly-sensitive assay (hs-cTnT).
Methods:
We conducted a cross-sectional analysis of 9351 participants from the Atherosclerosis Risk in the Communities (ARIC) Study with information on ALT, AST and GGT , hs-cTnT, and no evidence of coronary heart disease or elevated alcohol consumption (>14 and >21 drinks/week for women and men, respectively). We used logistic regression models to examine the association between liver enzymes and elevated hs-TnT (hs-TnT >0.014 μ g/L ) defined in a healthy reference population. Our secondary outcome was detectable hs-TnT (>0.003 μ g/L ).
Results:
In this community-based population (mean age 63 years, 60% women, 78% white), 7.2% and 66.1% had elevated and detectable hs-TnT, respectively. Medians [range] of ALT, AST and GGT were 13 [1-381], 18 [5-358] and 21 [2-1277], respectively. Higher levels of ALT, AST and GGT, even within the normal range, were independently associated with elevated hs-TnT (Figure). ALT and AST were also independently associated with detectable hs-TnT. After excluding participants with heart failure, the results remained consistent.
Conclusions:
In this sample, elevated livers enzymes were independently associated with subclinical myocardial damage suggesting that NAFLD may contribute to myocardial injury beyond its effects on development of clinical atherosclerotic coronary disease.
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Details
- Title
- Abstract P009: The Association of Liver Enzymes with Subclinical Myocardial Damage
- Creators
- Mariana Lazo - Bloomberg (United States)Jonathan Rubin - Bloomberg (United States)Jeanne M Clark - Johns Hopkins MedicineFrederick L Brancati - Johns Hopkins MedicineAndrea Christman - Bloomberg (United States)Chiadi Ndumele - Bloomberg (United States)Ron C Hoogeveen - Baylor College of MedicineChristie M Ballantyne - Baylor College of MedicineElizabeth Selvin - Bloomberg (United States)
- Publication Details
- Circulation (New York, N.Y.), v 125(suppl_10)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Other Identifier
- 991020550492204721