Journal article
Abstract P243: Long-Term Exposure to Air Pollution and Markers of Inflammation, Coagulation and Endothelial Activation: A Repeat Measures Analysis in the Multi-Ethnic Study of Atherosclerosis
Circulation (New York, N.Y.), v 129(suppl_1)
25 Mar 2014
Abstract
Air pollution is associated with CVD and systemic inflammation is posited to mediate this effect. Animal, experimental and epidemiologic studies suggest that increases in short-term air pollution cause an inflammatory response. Few studies, however, have assessed the contribution of long-term exposure to pollutants even though chronic inflammation may be more relevant to the observed risk of atherosclerotic disease. We assessed the hypothesis that long-term exposure to pollutants is associated with markers of inflammation, coagulation and endothelial activation.
We studied participants from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort with repeat measures of serum C-reactive protein (CRP), fibrinogen, D-dimer, soluble E-selectin and soluble Intercellular Adhesion Molecule-1 (sICAM-1). We estimated associations of these markers with outdoor PM2.5, individual-level ambient PM2.5 (integrating indoor concentrations and time-location data) and oxides of nitrogen (NOX). Pollutant concentrations were predicted from likelihood based models from cohort-specific monitoring and were averaged over the year prior to blood draw. CRP and D-Dimer were log-transformed for analysis. A random effects model controlling for relevant covariates was used to account for within person clustering. Participants with a recent history of acute infection were excluded from analysis.
A total of 713 participants contributed 1736 observations (mean 1.8 observations per person over 3 visits). After excluding those with a recent infection we were left with 1233 observations among 491 participants. In multivariable models, both D-dimer and E-selectin were associated with pollutants, specifically PM2.5 and NOx (see table). There was no association between pollutants and CRP, fibrinogen or sICAM-1.
In conclusion, these data are consistent with the hypothesis that associations between long-term exposure to particulate and traffic-related air pollution and CVD may be related to endothelial activation and fibrinolysis.
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Details
- Title
- Abstract P243: Long-Term Exposure to Air Pollution and Markers of Inflammation, Coagulation and Endothelial Activation: A Repeat Measures Analysis in the Multi-Ethnic Study of Atherosclerosis
- Creators
- Anjum Hajat - University of WashingtonAna V Diez-Roux - University of MichiganNancy Jenny - University of VermontAdam Szpiro - University of WashingtonJoel Kaufman - University of Washington
- Publication Details
- Circulation (New York, N.Y.), v 129(suppl_1)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Drexel University
- Other Identifier
- 991020112187104721