Journal article
Abstract P389: Smoking, Biomarkers and Ischemic Stroke Risk: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort
Circulation (New York, N.Y.), v 139(Suppl_1)
05 Mar 2019
Abstract
Introduction:
Identifying biological pathways that mediate the increased stroke risk in smokers may allow study of novel strategies to reduce risk. In the REGARDS study, we evaluated the association of smoking status with incident stroke and assessed biomarkers as mediators of smoking related stroke.
Methods:
30,239 black and white adults aged 45 and older were enrolled in 2003-7, and followed for incident stroke. Biomarkers were measured in a case cohort substudy and compared across groups of smoking status (never, former or current). Hazard ratios (HRs) of stroke by smoking status and by pack years were calculated using Cox proportional hazards models.
Results:
Among 1,224 participants with biomarker data (mean age 62, 50% male, 50% black) there were 531 incident stroke cases over 12.9 yrs maximal follow up. Compared to never smokers, the multivariable (age, race, sex and Framingham risk factors) adjusted HR of stroke in current smokers was 1.30 (95% CI 1.11, 1.53) and in former smokers was 1.18 (95% CI 1.05, 1.32). The association of pack years with stroke was substantial in current smokers and weak in former smokers in the adjusted model (Table). Among 7 biomarkers, white blood count, interleukin-6 (IL-6) and fibrinogen were higher in former and current smokers, and with increasing pack years in both groups (data not shown). The association of pack years with stroke in current smokers was partly attenuated with adjustment for IL-6, but not white count or fibrinogen. Among former smokers, white count fully attenuated the weak association.
Conclusions:
Former and current smoking, and pack years (primarily among current smokers) were stroke risk factors in a contemporary biracial cohort. Among both current and former smokers, smoking-related stroke risk was attenuated after adjustment for IL-6 and white count respectively, suggesting biological pathways for intervention.
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Details
- Title
- Abstract P389: Smoking, Biomarkers and Ischemic Stroke Risk: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort
- Creators
- Juan Conde - University of VermontMaxwell Pistilli - Drexel UniversityTimothy Plante - University of VermontNeil Zakai - University of VermontLeslie McClure - Drexel UniversityNels Olson - University of VermontGeorge Howard - University of Alabama at BirminghamMary Cushman - University of Vermont
- Publication Details
- Circulation (New York, N.Y.), v 139(Suppl_1)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000478079000329
- Other Identifier
- 991019169517204721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Peripheral Vascular Disease