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Abstract WP111: Who Needs Neuroprotection With Endovascular Stroke Therapy? Findings From the Trevo Retriever Registry
Journal article   Peer reviewed

Abstract WP111: Who Needs Neuroprotection With Endovascular Stroke Therapy? Findings From the Trevo Retriever Registry

David S Liebeskind, Yanchang Zhang, Erol Veznedaroglu, Joey English, Blaise W Baxter, Ronald F Budzik, Bruno M Bartolini, Antonin Krajina, Ali Malek, Amrou Sarraj, …
Stroke (1970), v 50(Suppl_1)
Feb 2019
DOI: https://doi.org/10.1161/str.50.suppl_1.WP111

Abstract

Background: Combined neuroprotection with endovascular therapy may improve clinical outcomes of only a subset of individuals treated for acute ischemic stroke. The risk/benefit profile of adjunctive treatment may not warrant neuroprotection with successful reperfusion, yet many other individuals have poor outcomes despite revascularization. We hypothesized that optimal candidates for adjunctive neuroprotection may be defined by analyses of subjects with poor clinical outcome despite successful reperfusion in the Trevo Retriever Registry. Methods: The Trevo Retriever Registry dataset was analyzed to define the subset of cases with poor clinical outcome (day 90 mRS 4-6) after successful reperfusion (eTICI 2b50, 2b67, 2c, 3). Multivariate analyses were used to identify predictors of poor outcome using these distinct definitions of successful reperfusion. The influence of covariates, including TLSW, baseline clinical and imaging variables (e.g. ASPECTS, ASITN collateral grade), on defining such optimal neuroprotective candidates was delineated. Results: Successful reperfusion adjudicated by core lab, defined as eTICI ≥ 2b50 included 1,162 subjects, with eTICI ≥ 2b67 in 920, eTICI ≥ 2c in 652 and eTICI 3 in 209. Poor outcome (day 90 mRS 4-6) occurred in 316/1162 (27%) with eTICI ≥ 2b50, 243/920 (26%) with eTICI ≥ 2b67, 172/652 (26%) with eTICI ≥ 2c and 61/209 (29%) with eTICI 3. Across all subsets, multivariate analyses to predict poor outcome after successful reperfusion identified increased age (per year, OR 1.04-1.05, all p=<0.02) as a factor, adjusting for withdrawal of care. Expectedly, greater baseline NIHSS severity predicted greater day 90 disability (OR 1.07-1.08, all p<0.001). TLSW was a predictor only with eTICI ≥ 2b50 (per hour, OR 1.02, p=0.039). History of diabetes was a factor only with eTICI ≥ 2b50 and eTICI ≥ 2b67 (OR 2.05-2.19, p<0.001). Worse collateral grade (ASITN 0-1) was the most potent predictor (OR 2.27-2.71 versus ASITN 2, p=0.027-0.052; OR 3.85-4.35 versus ASITN 3-4, all p=0.003). Conclusions: Neuroprotection combined with endovascular therapy may optimally target stroke patients with worse collaterals, diabetes or increased age. Trial design for neuroprotection with revascularization in AIS should leverage these data.

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