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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Accelerometer-measured Physical Activity, Reproductive Hormones, and DNA Methylation
Medicine and science in sports and exercise, v 52(3), pp 598-607
Mar 2020
PMID: 31652236
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Limited studies have examined the association of physical activity with reproductive hormones, DNA methylation, and pubertal status among adolescents.
Among 248 boys and 271 girls, we estimated daily physical activity levels based on 7 d of wrist-worn accelerometer data. We used an isotemporal substitution paradigm and sex-stratified regression models to examine the association of physical activity levels with 1) testosterone, cortisol, progesterone, and androstenedione concentrations; 2) DNA methylation of long interspersed nucleotide (LINE-1) repeats and the genes H19, hydroxysteroid (11-Beta) dehydrogenase 2 (HSD11B2), and peroxisome proliferator-activated receptor alpha (PPARA) from blood leukocytes; and 3) Tanner stages, adjusted for age, BMI, and socioeconomic status.
In boys, substituting 30 min of moderate physical activity for 30 min of sedentary behavior per day was associated with 29% (-49%, 0%) of lower testosterone and 29% (4%, 61%) of higher progesterone. Substituting 30 min of light physical activity for sedentary behavior was associated with 13% (-22%, -2%) of lower progesterone. Among girls, 30 min of additional sedentary behavior was associated with 8% (-15%, 0%) of lower testosterone and 24% (8%, 42%) of higher progesterone concentrations. Substituting 30 min of moderate physical activity for sedentary behavior was associated with 15% (0%, 31%) of higher cortisol, whereas substituting the same amount of light physical activity for sedentary behavior was associated with 22% (-39%, 0%) of lower progesterone. Substituting 30 min of vigorous physical activity for sedentary behavior per day was associated with almost six times higher levels (5.83, 95% confidence interval = 1.79-9.86) of HSD11B2 methylation in boys.
Accelerometer-measured daily physical activity was associated with reproductive hormones and HSD11B2 DNA methylation, differed by sex and activity intensity levels.
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Details
- Title
- Accelerometer-measured Physical Activity, Reproductive Hormones, and DNA Methylation
- Creators
- Yue Wu - University of MichiganJaclyn M Goodrich - University of MichiganDana C DolinoyBrisa N SÁnchez - University of MichiganEdward A Ruiz-NarvÁez - University of MichiganMargaret Banker - University of MichiganAlejandra Cantoral - Center for Research on Nutrition and Health, National Institute of Public Health, Cuernavaca, Morelos, MEXICO.Adriana Mercado-Garcia - Center for Research on Nutrition and Health, National Institute of Public Health, Cuernavaca, Morelos, MEXICO.Martha M TÉllez-Rojo - Center for Research on Nutrition and Health, National Institute of Public Health, Cuernavaca, Morelos, MEXICO.Karen E Peterson - University of Michigan
- Publication Details
- Medicine and science in sports and exercise, v 52(3), pp 598-607
- Grant note
- R01 ES007821 / NIEHS NIH HHS P30 DK020572 / NIDDK NIH HHS P20 ES018171 / NIEHS NIH HHS R01 ES013744 / NIEHS NIH HHS R01 ES014930 / NIEHS NIH HHS P01 ES022844 / NIEHS NIH HHS P30 ES017885 / NIEHS NIH HHS P30 DK089503 / NIDDK NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000514884400010
- Scopus ID
- 2-s2.0-85079354193
- Other Identifier
- 991020099918904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Sport Sciences