Journal article
Accommodative and Vergence Responses to a Moving Stimulus in Concussion
Investigative ophthalmology & visual science, v 65(12), 45
01 Oct 2024
PMID: 39475939
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Concussed adolescents often report visual symptoms, especially for moving targets, but the mechanisms resulting in oculomotor deficits remain unclear. We objectively measured accommodative and vergence responses to a moving target in concussed adolescents and controls.
Thirty-two symptomatic concussed participants (mean age, 14.4 ± 2.6 years; mean days since concussion, 107 days; range, 36-273 days) and 32 healthy controls (mean age, 12.7 ± 2.1 years) viewed a movie binocularly (closed-loop) and monocularly (vergence open-loop), as well as a Difference of Gaussians (DoG) target binocularly (accommodation open-loop). The movie or DoG target sinusoidally moved toward and away from participants at a 0.1-hertz (Hz) frequency at four separate stimulus amplitudes (1.50 diopters [D], 1.00 D, 0.50 D, 0.25 D) around a 2.50-D midpoint. Accommodation and vergence were continuously measured at 50 Hz using the PowerRef 3. Fourier analysis was used to assess the response amplitudes at the 0.1-Hz frequency. A 2 × 3 analysis of variance with the factors group (concussed, control) and viewing condition (binocular, monocular, DoG) was conducted on response amplitudes.
Across groups, accommodative and vergence responses were significantly higher in binocular than monocular conditions (P < 0.001), but not DoG conditions. Compared to controls, concussed participants had significantly reduced monocular accommodative responses (P < 0.012; e.g., at 1.50 D, controls = 1.09 ± 0.47 D and concussed = 0.80 ± 0.36 D, P = 0.011). No group differences were observed for vergence responses in any viewing condition.
Accommodative and vergence responses to the moving target were largely driven by disparity cues for both groups, with only minimal improvements in the presence of additional blur cues. Concussed participants showed reduced accommodative responses to a 0.1-Hz stimulus in monocular conditions, indicating mild accommodative deficits in the absence of disparity cues.
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Details
- Title
- Accommodative and Vergence Responses to a Moving Stimulus in Concussion
- Creators
- Jennifer X Haensel - Stanford UniversitySophia Marusic - Boston Children's HospitalKristin E Slinger - Smith-Kettlewell Eye Research InstituteCarissa H Wu - Boston Children's HospitalNeerali Vyas - Boston Children's HospitalChristabel A Ameyaw BaahAmber Hu - Smith-Kettlewell Eye Research InstituteJoellen Leonen - Smith-Kettlewell Eye Research InstituteCaitlyn Y Lew - Smith-Kettlewell Eye Research InstituteGayathri Srinivasan - Smith-Kettlewell Eye Research InstituteAmir Norouzpour - Smith-Kettlewell Eye Research InstituteErin Jenewein - Salus UniversitySiva Meiyeppen - Salus UniversityMitchell Scheiman - Salus UniversityAparna Raghuram - Boston Children's HospitalTawna L Roberts - Stanford University
- Publication Details
- Investigative ophthalmology & visual science, v 65(12), 45
- Publisher
- ARVO
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biomedicine; Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:001349687600002
- Scopus ID
- 2-s2.0-85208167974
- Other Identifier
- 991021985199504721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Ophthalmology