Journal article
Accurate optical parameter extraction procedure for broadband near-infrared spectroscopy of brain matter
Journal of biomedical optics, v 18(1), pp 17008-017008
Jan 2013
PMID: 23322361
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Modeling behavior of broadband (30 to 1000 MHz) frequency modulated near-infrared (NIR) photons through a phantom is the basis for accurate extraction of optical absorption and scattering parameters of biological turbid media. Photon dynamics in a phantom are predicted using both analytical and numerical simulation and are related to the measured insertion loss (IL) and insertion phase (IP) for a given geometry based on phantom optical parameters. Accuracy of the extracted optical parameters using finite element method (FEM) simulation is compared to baseline analytical calculations from the diffusion equation (DE) for homogenous brain phantoms. NIR spectroscopy is performed using custom-designed, broadband, free-space optical transmitter (Tx) and receiver (Rx) modules that are developed for photon migration at wavelengths of 680, 780, and 820 nm. Differential detection between two optical Rx locations separated by 0.3 cm is employed to eliminate systemic artifacts associated with interfaces of the optical Tx and Rx with the phantoms. Optical parameter extraction is achieved for four solid phantom samples using the least-square-error method in MATLAB (for DE) and COMSOL (for FEM) simulation by fitting data to measured results over broadband and narrowband frequency modulation. Confidence in numerical modeling of the photonic behavior using FEM has been established here by comparing the transmission mode's experimental results with the predictions made by DE and FEM for known commercial solid brain phantoms.
Metrics
Details
- Title
- Accurate optical parameter extraction procedure for broadband near-infrared spectroscopy of brain matter
- Creators
- Ebraheem Sultan - Drexel University, Department of Electrical and Computer Engineering, Philadelphia, Pennsylvania, USA. medxe@medxe.comLaleh NajafizadehAmir H GandjbakhcheKambiz PourrezaeiAfshin Daryoush
- Publication Details
- Journal of biomedical optics, v 18(1), pp 17008-017008
- Publisher
- Society of Photo-Optical Instrumentation Engineers (SPIE); United States
- Grant note
- Intramural NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Electrical and Computer Engineering; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000315157000029
- Scopus ID
- 2-s2.0-84878249961
- Other Identifier
- 991014878030004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemical Research Methods
- Optics
- Radiology, Nuclear Medicine & Medical Imaging